Sort   by:  
 Page size 
ProteomicsImmunogenicity of non-canonical HLA-I tumor ligands identified through proteogenomics
Tumor antigens are central to antitumor immunity. Recent evidence suggests that peptides from non-canonical (nonC) aberrantly translated proteins can be presented on HLA-I by tumor cells. Here, we investigated the presentation and immunogenicity of nonC antigens across different cancer types to bett...
ORGANISM(S): Homo sapiens (Human) 
2023-02-03 | PXD036856 | Pride
Human Non-canonical hla-i ligands 
ProteomicsZapnometinib treatment and influenza A virus infection induce alteration on the HLA class I ligandome of human lung adenocarcinoma cells
Targeting cellular factors is considered a promising approach to combat viral infection and overcome the resistance issue associated with direct-acting antiviral (DAA) drugs administration. In the context of drug repurposing strategies, we have previously explored the antiviral efficacy of the MEK i...
ORGANISM(S): Homo sapiens (Human) 
2026-06-15 | PXD041578 | Pride
Influenza a virus Ligandome analysis Mek inhibitors Zapnometinib Mhc-i Lc-ms/ms 
ProteomicsT cells of colorectal cancer patients’ stimulated by neoantigenic and cryptic peptides better recognize autologous tumor cells
Immunopeptidome analysis of patient-derived colorectal cancer cell lines HROC113 and HROC285 T0 M2 from the HROC collection [Mullins et al. Cancers (Basel). 2019;11(10):1520. doi: 10.3390/cancers11101520] was performed to characterize the natural HLA class I presented ligandome in native as well as ...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD037587 | Pride
Hla-presented peptides  neoepitope Colorectal cancer Human Hla class i Antigen presentation Lc-msms 
UnknownIDH2 reprograms mitochondrial dynamics in cancer through a HIF-1α-regulated pseudohypoxic state.
Not available
S-EPMC6894043 | biostudies-literature
ProteomicsThe impact of biomaterial cell contact on the immunopeptidome
Biomaterials play an increasing role in clinical applications and regenerative medicine. Modern biomaterials should imitate the function of damaged tissue without triggering an immune response, initiate self-regeneration of the body and gradually degrade after implantation. The immune system is now ...
ORGANISM(S): Homo sapiens (Human) 
2020-12-01 | PXD019258 | Pride
Monocytes Foreign body response Biocompatibility Mass spectrometry Immunopeptidomics Host response Biocompatibility assay Biomaterials 
ProteomicsMapping the HLA ligandome of Colorectal Cancer Reveals an Imprint of Malignant Cell Transformation
Immunopeptidome analysis of colorectal adenocarcinoma tissues as well as adjacent benign tissues was performed to characterize the natural HLA class I and class II presented ligandome represented in the context of malignancy as well as in benign tissue of the colon.
ORGANISM(S): Homo sapiens (Human) 
2019-03-12 | PXD009602 | Pride
Neoplasia Cancer Hla-ligandomics Hla Colorectal adenocarcinoma Colon cancer Peptide Hla-restricted peptide Hla-ligand Colon 
UnknownExperimental and Computational Studies Delineate the Role of Asparagine 177 in Hydride Transfer for E. coli Thymidylate Synthase.
Not available
S-EPMC6605054 | biostudies-literature
UnknownCooperative Effects in Switchable Catalysis: Enhancing Double-Click Reaction Yield of Symmetrical Rotaxanes.
Not available
S-EPMC8457069 | biostudies-literature
UnknownExploring the Immunogenicity of Noncanonical HLA-I Tumor Ligands Identified through Proteogenomics.
Not available
S-EPMC10261919 | biostudies-literature
UnknownRemote Control of the Synthesis of a [2]Rotaxane and its Shuttling via Metal-Ion Translocation.
Not available
S-EPMC6863578 | biostudies-literature
Sort   by:  
 Page size