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TranscriptomicsTranscription profiling of human peripheral blood from relapsing-remitting MS patients either untreated or treated with glatiramer acetate or interferon beta
One of our new major finding among the genes that contributes to MS susceptibility is ICSBP1. The so called disease modifying therapies like interferon-beta (IFN-β), possibly acting on the peripheral T-cells, reduce the disease activity and the clinical progression, with a MRI-detectable effect in ...
ORGANISM(S): Homo sapiens 
2009-08-09 | E-GEOD-16214 | biostudies-arrayexpress
GenomicsA Case-Controlled Study for Genotype-Phenotype Associations in Multiple Sclerosis (MS)

This is a multi-centre, case-controlled study to develop a dataset containing 1000 MS cases and 1000 matched controls and to associate DNA sequence (allelic) variations with MS phenotypes.

Study subjects were enrolled through a prospective effort initiated in 2003. Three MS clinical ce...

phs000171.v1.p1 | EGA
GenomicsBrigham and Women's Hospital Multiple Sclerosis Genetic Collection

The main objective of this GWA study is to identify Multiple Sclerosis (MS) susceptibility loci. Whole-genome association analysis was performed on 924 individuals genotyped on the Affymetrix 6.0 Genechip. The cohort consisted of 860 clinically diagnosed MS patients and 64 control subjects.

phs000275.v1.p1 | EGA
ProteomicsEffects of lipid diets on the metaproteome of mouse colon mucosa
Eight mice colon samples were submitted for iTRAQ labeling, high pH reversed phase fractionation and LC-MS/MS analysis.
ORGANISM(S): Mus musculus (Mouse) Bacteroidetes Firmicutes bacterium 
2019-02-20 | PXD008152 | Pride
Fatty acids Lipid diet Metaproteome Mouse Itraq Colon mucosa 
ProteomicsEffects of lipid diets on the metaproteome of the mice colon submucosa
Eight mice colon (submucosa) samples were submitted for iTRAQ labeling, high pH reversed phase fractionation and LC-MS/MS analysis.
ORGANISM(S): Mus musculus (Mouse) Bacteroidetes Firmicutes MN01-01 
2019-02-20 | PXD008165 | Pride
Lipid diet Metaproteome Submucosa Mice Colon Itraq 
ProteomicsDesign, Implementation and Multisite Evaluation of a System Suitability Protocol for the Quantitative Assessment of Instrument Performance in Liquid Chromatography-Multiple Reaction Monitoring-MS (LC-MRM-MS)
Multiple reaction monitoring (MRM) mass spectrometry coupled with stable isotope dilution (SID) and liquid chromatography (LC) is increasingly used in biological and clinical studies for precise and reproducible quantification of peptides and proteins in complex sample matrices. Robust LC-SID-MRM-MS...
ORGANISM(S): Bos Taurus 
PXD010535 | panorama
MetabolomicsLongitudinal multi-omics reveals subset-specific mechanisms underlying irritable bowel syndrome

The gut microbiome has been implicated in multiple human chronic gastrointestinal (GI) disorders. Determining its mechanistic role in disease has been difficult due to apparent disconnects between animal and human studies and lack of an integrated multi-omics view of disease-specific physiologica...

2020-09-08 | MTBLS1396 | MetaboLights
TranscriptomicsThe PhtL protein of Pseudomonas syringae pv. phaseolicola NPS3121 affects the expression of both phaseolotoxin cluster (Pht) and Non-Pht encoded genes
P. syringae pv. phaseolicola, the causal agent of halo blight disease in bean, produces a toxin known as phaseolotoxin, whose synthesis involves the product of some of the genes found within the Pht region. This region, considered a pathogenicity island, comprises 23 genes arranged in five transcrip...
ORGANISM(S): Pseudomonas syringae pv. phaseolicola 
2013-12-28 | E-GEOD-44554 | biostudies-arrayexpress
ProteomicsTMPRSS2-mediated coronavirus spike activation and inhibition
The human protease TMPRSS2 facilitates entry of many respiratory viruses into cells, including coronaviruses and influenza viruses, yet its mechanism or viral glycoprotein recognition remains unclear. Here, we show that following ACE2 engagement and formation of an early fusion intermediate SARS-CoV...
ORGANISM(S): Homo sapiens (Human) 
2026-03-27 | PXD069687 | Pride
Sars-cov-2 
UnknownDesign, implementation and multisite evaluation of a system suitability protocol for the quantitative assessment of instrument performance in liquid chromatography-multiple reaction monitoring-MS (LC-MRM-MS).
Not available
S-EPMC3769335 | biostudies-literature
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