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TranscriptomicsEvolution of neuronal and endothelial transcriptomes in primates
Neurons and endothelial cells were identified by immunohistochemistry in human brains, isolated by laser-capture-microdissection and used to find genes preferentially expressed in the two cell types. Keywords: cell type comparison Laser capture microdissection was used to isolate approximately 1000...
ORGANISM(S): Homo sapiens 
2010-06-08 | E-GEOD-12293 | biostudies-arrayexpress
TranscriptomicsWidespread over-expression of the X chromosome in sterile F1 hybrid mice
We used a reciprocal cross of Mus musculus and M. domesticus in which F1 males are sterile in one direction and fertile in the other direction, in order to associate expression differences with sterility. Four different crosses were performed. A cross between two strains within each mouse species (M...
ORGANISM(S): Mus musculus musculus x M. m. domesticus 
2010-10-05 | E-GEOD-17684 | biostudies-arrayexpress
TranscriptomicsLaser capture microdissection of endothelial and neuronal cells from human dorsolateral prefrontal cortex
We used laser capture microdissection to isolate both microvascular endothelial cells and neurons from post mortem brain tissue from patients with schizophrenia and bipolar disorder and healthy controls. RNA was isolated from these cell populations, amplified, and analysed using Affymetrix HG133plus...
ORGANISM(S): Homo sapiens 
2008-12-18 | E-GEOD-12679 | biostudies-arrayexpress
TranscriptomicsComparison of expression profiles of once and three time linearly amplified samples
In order to assess the impact of three rounds of linear amplification on the technical reproducibility of gene expression measurements, we performed twelve microarray experiments. We analysed mouse RNA from cortex, cerebellum and liver from one individual. One RNA sample of 5µg from each of the thr...
ORGANISM(S): Mus musculus 
2010-06-08 | E-GEOD-21389 | biostudies-arrayexpress
TranscriptomicsGene expression changes during primate postnatal brain development
In development, timing is of the utmost importance, and the timing of various developmental processes are often changed during evolution. During human evolution sexual maturation has been delayed relative to other primates and this may have played a critical role for both the increase of human brain...
ORGANISM(S): Macaca mulatta 
2009-03-09 | E-GEOD-11512 | biostudies-arrayexpress
TranscriptomicsGene expression in striatums of Foxp2-hum, Foxp2-ko and wild-type mice
It has been proposed that two amino acid substitutions in the transcription factor FOXP2 have been positively selected during human evolution due to effects on aspects of speech and language. Here, we introduce these substitutions into the endogenous Foxp2 gene.of mice. Although these mice are gener...
ORGANISM(S): Mus musculus 
2010-05-22 | E-GEOD-13588 | biostudies-arrayexpress
Genomicsena-DATASET-GenCord2-22-05-2013-15:33:28:221-28 - samples
GENCORD2 RNA-seq BAM files using BWA
EGAD00001000425 | EGA
GenomicsGENCORD2_DNAmethylation - samples
GENCORD2 DNA methylation
EGAD00010000460 | EGA
Genomicsena-DATASET-GenCord2-27-05-2013-09:30:55:905-40 - samples
204 individuals were genotyped with the Illumina 2.5M Omni chip. Filtered genotypes were imputed into the 1000 genomes project European panel SNPs. Beagle R2 is indicated in VCF files for further filtering. See Materials and Methods in publication for details.
EGAD00001000428 | EGA
GenomicsPassive and active DNA methylation and the interplay with genetic variation in gene regulation
DNA methylation is an essential1 epigenetic mark whose role in gene regulation and its dependency on genomic sequence and environment are not yet fully understood2,3. In this study we provide novel insights into the mechanistic relationships between genetic variation, DNA methylation and transcripto...
EGAS00001000446 | EGA
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