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ProteomicsTranslational repression of NMD targets by GIGYF2 and EIF4E2
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027479 | Pride
Nmd Eif4e2 Gigyf2 Translation 
ProteomicsInteractome of GIGYF2 and EIF4E2 with and without SMG1i treatement
Translation of messenger RNAs (mRNAs) with premature translation termination codons produces truncated proteins with potentially deleterious effects. This is prevented by nonsense-mediated mRNA decay (NMD) of these mRNAs. NMD is triggered by ribosomes terminating upstream of a splice site marked by ...
ORGANISM(S): Homo sapiens (Human) 
2021-10-12 | PXD027487 | Pride
Nmd Smg1i Gigyf2. eif4e2 
UnknownTranslational repression of NMD targets by GIGYF2 and EIF4E2.
Not available
S-EPMC8555832 | biostudies-literature
Genomics
Ribosome Footprint Profiling of GIGYF2/EIF4E2 ko
PRJNA675773 | ENA
UnknownThe eIF4E homolog 4EHP (eIF4E2) regulates hippocampal long-term depression and impacts social behavior.
Not available
S-EPMC7682028 | biostudies-literature
GenomicsEDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response
EDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response
PRJNA629288 | ENA
GenomicsGIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
GIGYF2 and 4EHP Inhibit Translation Initiation of Defective Messenger RNAs to Assist Ribosome-Associated Quality Control
PRJNA643292 | ENA
UnknownThe SARS-CoV-2 protein NSP2 enhances microRNA-mediated translational repression.
Not available
S-EPMC10617620 | biostudies-literature
TranscriptomicsEDF1 binds collided ribosomes and facilitates recruitment of translational repressors GIGYF2/EIF4E2 and initiates JUN-mediated transcriptional response
RNA-seq analyses of wild-type and DEDF1 cell lines show that the immediate-early JUN-dependent transcriptional response to collisions is dependent on EDF1.
ORGANISM(S): Homo sapiens 
2020-08-02 | GSE149565 | GEO
UnknownEDF1 coordinates cellular responses to ribosome collisions.
Not available
S-EPMC7486125 | biostudies-literature
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