Gilchrist Daniel A DA

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Upstream Anti-sense Promoters Act as Local Enhancers of Mammalian Protein-coding Genes

Anti-sense transcription originating upstream of mammalian protein-coding genes is a well-documented phenomenon, but remarkably little is known about the function or regulation of these anti-sense promoters or the non-coding RNAs they generate. Here we define at nucleotide resolution the divergent t...

ORGANISM(S): Mus musculus

2015-06-23 | E-GEOD-62151 | biostudies-arrayexpress

Pol II (Rpb3) ChIP-seq in Drosophila melanogaster S2 cells

Control of RNA transcription is critical for the development and homeostasis of all organisms, and can occur at multiple steps of the transcription cycle, including RNA polymerase II (Pol II) recruitment, initiation, promoter-proximal pausing, and elongation. That Pol II accumulates on many promoter...

ORGANISM(S): Drosophila melanogaster

2012-10-25 | E-GEOD-23542 | biostudies-arrayexpress

RNA polymerase is poised for activation across the genome

Regulation of gene expression is integral to the development and survival of all organisms. Transcription begins with the assembly of a pre-initiation complex at the gene promoter, followed by initiation of RNA synthesis and the transition to productive elongation. In many cases, recruitment of RNA ...

ORGANISM(S): Drosophila melanogaster

2007-11-11 | E-GEOD-6714 | biostudies-arrayexpress

Pausing of RNA polymerase II disrupts DNA-specified nucleosome organization to enable precise gene regulation: Expression data

Metazoan transcription is controlled through either coordinated recruitment of transcription machinery to the gene promoter, or subsequently, through regulated pausing of RNA polymerase II (Pol II) in early elongation. We report that a key difference between genes that use these distinct regulatory ...

ORGANISM(S): Drosophila melanogaster

2010-10-18 | E-GEOD-24133 | biostudies-arrayexpress

Prospective Assessment of the Feasibility of a Trial of Low-Tidal Volume Ventilation for Patients with Acute Respiratory Failure.

Not available

S-EPMC6394119 | biostudies-literature

A second update on mapping the human genetic architecture of COVID-19.

Not available

S-EPMC10482689 | biostudies-literature

Convalescent plasma in patients admitted to hospital with COVID-19 (RECOVERY): a randomised controlled, open-label, platform trial.

Not available

S-EPMC8121538 | biostudies-literature

Duration of androgen deprivation therapy with postoperative radiotherapy for prostate cancer: a comparison of long-course versus short-course androgen deprivation therapy in the RADICALS-HD randomised trial.