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MetabolomicsUntargeted metabolomics analysis of gingival tissue in patients with severe periodontitis
Periodontitis, as a chronic inflammatory condition, its initiating factor is the plaque biofilm. The inflammation starts in the gingival tissue, if left untreated, may progress to severe periodontitis and cause bone and tooth loss. The purpose of this study was to determine the potential metabolic b...
2026-09-08 | MTBLS8357 | MetaboLights
TranscriptomicsTranscription profiling of gingival tissue from patients with periodontitis: Bacterial Correlates of Gingival Gene Expression
We investigated the association between subgingival bacterial profiles and gene expression patterns in gingival tissues of patients with periodontitis. A total of 120 patients undergoing periodontal surgery contributed with a minimum of two interproximal gingival papillae (range 2-4) from a maxillar...
ORGANISM(S): Homo sapiens 
2009-12-21 | E-GEOD-16134 | biostudies-arrayexpress
TranscriptomicsMicroRNAs and their target genes in gingival tissues.
To gain insights into the in vivo function of miRNAs in the context of periodontitis, we examined the occurrence of miRNAs in healthy and diseased gingival tissues and validated their in silico-predicted targets through mRNA profiling using whole-genome microarrays in the same specimens. Eighty-six ...
ORGANISM(S): Homo sapiens 
2014-02-05 | E-GEOD-54710 | biostudies-arrayexpress
TranscriptomicsTranscriptomes in Healthy and Diseased Gingival Tissues
We examined gene expression signatures in healthy and diseased gingival tissues in 90 patients. Analysis of the gingival tissue transcriptome in states of periodontal health and disease may reveal novel insights of the pathobiology of periodontitis. Keywords: gingival tissue disease state analysis N...
ORGANISM(S): Homo sapiens 
2008-12-22 | E-GEOD-10334 | biostudies-arrayexpress
TranscriptomicsExpression profiling in HGF (Hereditary Gingival Fibromatosis) patients
To identify dysregulated genes in HGF (Hereditary Gingival Fibromatosis) patients, expression profiling was performed using Affymetrix Human Genome U133 plus 2.0 arrays. Total RNA was extracted from gingival tissue specimens excised from two non-syndromic HGF patients, siblings in one family, and th...
ORGANISM(S): Homo sapiens 
2019-12-31 | E-MTAB-7801 | biostudies-arrayexpress
TranscriptomicsExpression data from gingival tissue
The experiment aims to identify transcriptional effects differences between periimplantitis, Parodontitis and healthy gingival tissue 8 controls, 7 periimplantitis patients, 7 Parodontitis patients
ORGANISM(S): Homo sapiens 
2012-10-29 | E-GEOD-33774 | biostudies-arrayexpress
TranscriptomicsOntogeny of Innate Immunity in Oral Mucosa - Cross Sectional
mRNA microarray profiling was performed on healthy gingival biopsies from nonhuman primates (NHPs) (between 3 and 23 years old, and periodontitis gingival biopsies from NHPs (12-22 years old)
ORGANISM(S): Macaca mulatta 
2014-10-15 | E-MTAB-1977 | biostudies-arrayexpress
ProteomicsPCT-assisted mass spectrometric quantification of gingival tissue reveals dynamics of protein synthesis during initiation and progression of inflammatory disease
Understanding the progression of periodontal destruction is at the forefront of periodontal research. Therefore, we aimed to capture the dynamics of gingival tissue proteome during initiation and progression of an experimental periodontitis developed by placing silk ligatures on the second molars of...
ORGANISM(S): Mus musculus (Mouse) 
2020-01-09 | PXD014608 | Pride
Experimental periodontitis Gingival tissue Pressure cycling technology Label-free quantitation Proteome Gingival inflammation Periodontitis Pct 
ProteomicsComparative Proteomics of Tissue and Gingival Crevicular Fluid in Periodontitis
Periodontitis is an inflammatory condition affecting periodontal tissues, such as the gingiva and alveolar bone, surrounding the teeth. However, previous research has focused on analyzing a single sample type, such as tissue, blood, or gingival crevicular fluid (GCF), which may limit the comprehensi...
ORGANISM(S): Homo sapiens (Human) 
2026-04-06 | PXD054953 | Pride
Proteomics Periodontitis Neutrophil Gcf Systemic inflammation 
GenomicsOral bacterial community dynamics during induction of gingival inflammation
Oral bacterial community dynamics during induction of gingival inflammation.
PRJEB83572 | ENA
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