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GenomicsPRMT5-mediated histone H4 arginine-3 symmetrical dimethylation marks chromatin at G+C-rich regions of the mouse genome.
Symmetrical dimethylation on arginine-3 of histone H4 (H4R3me2s) has been reported to occur at several repressed genes, but its specific regulation and genomic distribution remained unclear. Here, we show that the type-II protein arginine methyltransferase PRMT5 controls H4R3me2s in mouse embryonic ...
ORGANISM(S): Mus musculus domesticus x M. m. molossinus 
2013-10-04 | E-GEOD-37604 | biostudies-arrayexpress
TranscriptomicsChromatin immunoprecipitation of Mef2 protein in Drosophila during embryonic development
Genomewide mapping of Drosophila Mef2 protein binding during embryonic development. Five consecutive timepoints (2-4, 4-6, 6-8, 8-10, 10-12 hrs after egg-laying) were assayed in four independent repeats each. Two different antibodies were used to precipitate the Mef2 protein. Additionally the respec...
ORGANISM(S): Drosophila melanogaster 
2006-06-06 | E-TABM-56 | biostudies-arrayexpress
MetabolomicsCollected mass spectrometry data on monoterpene indole alkaloids from natural product chemistry research
MIADB: a cumulative collection of 172 tandem mass spectrometry (MS/MS) of a vast array of monoterpene indole alkaloids. Samples were analyzed using an Agilent LC-MS system composed of an Agilent 1260 Infinity HPLC coupled to an Agilent 6530 ESI-Q-TOF-MS operating in positive mode. A Sunfire analytic...
2018-12-03 | MTBLS142 | MetaboLights
TranscriptomicsSingle-cell RNA sequencing of a 3D blood-brain-barrier model perfused with P. falciparum-infected red blood cells and egress products
This dataset consists of two individual sample-multiplexing (MULTI-seq) single-cell RNA sequencing experiments, MB10x01 and MB10x02. Single-cell RNA sequencing (10X Genomics) analyses were performed on a microfluidic 3D in vitro blood-brain-barrier model (containing primary human brain microvascular...
ORGANISM(S): Homo sapiens 
2025-06-25 | E-MTAB-14463 | biostudies-arrayexpress
TranscriptomicsConstitutively active STAT5 recruits p53 to alternative transcriptional targets in myeloid cancers
In several cancer types, STAT (Signal transducer and activator of transcription) transcription factors are constitutively activated. We previously identified a target gene, LPP/miR-28 (LIM domain containing preferred translocation partner in lipoma), induced by constitutive activation of STAT5, but ...
ORGANISM(S): Homo sapiens 
2014-02-01 | E-GEOD-38143 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of Drosophila Mef2 homozygous mutant embryos in a timecourse of embryogenesis
Expression profiling of Drosophila Mef2 homozygous mutant embryos in a timecourse of embryogenesis. Twelve one-hour timepoints were assayed (5-16 hrs, 18-19 hrs after egg laying). Homozygous mutant embryos were collected using GFP-activated embryo sorting at the same time as stage-matched wildtype c...
ORGANISM(S): Drosophila melanogaster 
2006-06-06 | E-TABM-57 | biostudies-arrayexpress
GenomicsZFP57 recognizes multiple and closely spaced sequence motif variants to maintain repressive epigenetic marks in mouse embryonic stem cells
In mouse embryonic stem cells SNPs disrupting closely-spaced hexanucleotide motifs are associated with lack of ZFP57 binding and H3K9me3 enrichment. Examination of ZFP57-KAP1 allele-specific binding in two lines of mouse embryonic stem cells JB1 and BJ1 generated from F1 hybrids derived from JF1 x B...
ORGANISM(S): Mus musculus 
2015-11-06 | E-GEOD-74757 | biostudies-arrayexpress
TranscriptomicsNucleosome positioning in H3S57 mutants in yeast
In order to test the effect of H3S57 phosphorylation on nucleosome positioning in yeast, nucleosome were mapped in a WT strain, a strain with H3S57A mutation (phospho absent) and a strain H3S57E mutation (phospho mimicking).
ORGANISM(S): Saccharomyces cerevisiae 
2020-12-20 | E-MTAB-6901 | biostudies-arrayexpress
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