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TranscriptomicsTranscriptional profiling of PKH26-labeled colorectal cancer stem cells
Quiescent cancer cells responsible for tumor chemoresistance and relapse have been identified in several tumors but in colorectal cancer (CRC) they remain largely undefined. By using a proliferation-sensitive dye, we isolated and characterized a rare subpopulation of cells from colorectal tumors whi...
ORGANISM(S): Homo sapiens 
2022-09-30 | E-MTAB-12041 | biostudies-arrayexpress
UnknownMultiple myeloma-derived exosomes are enriched of amphiregulin (AREG) and activate the epidermal growth factor pathway in the bone microenvironment leading to osteoclastogenesis.
Not available
S-EPMC6325886 | biostudies-literature
TranscriptomicsIdentification of a DNA methylation signature in blood from subjects affected by Down syndrome
Down syndrome is characterized by a wide spectrum of clinical signs, which include cognitive and endocrine disorders and haematological abnormalities. Although it is well established that the causative defect of Down syndrome is the trisomy of chromosome 21, the molecular bases of Down syndrome phen...
ORGANISM(S): Homo sapiens 
2015-03-03 | E-GEOD-52588 | biostudies-arrayexpress
ProteomicsStructural obstruction to full DNA replication in the chromatin of terminally differentiated skeletal muscle cells
Terminal cell differentiation is often associated with permanent withdrawal from proliferation, termed the postmitotic state. Though widespread among vertebrates and determinant for their biology, the molecular underpinnings of this state are poorly understood. Postmitotic skeletal muscle myotubes c...
ORGANISM(S): Mus Musculus (ncbitaxon:10090) 
2025-01-13 | MSV000096839 | MassIVE
TranscriptomicsRNA-seq comparison of fibro-adipogenic progenitors (FAPs) from wild type, mdx and cardiotoxin-injured mice
We purified FAPs from the hind limbs of wild type, mdx and cardiotoxin-injured mice in order to unveil changes in their transcriptomes. RNA was isolated directly from sorted cells and analyzed by 3’ RNA sequencing.
ORGANISM(S): Mus musculus 
2019-06-20 | E-MTAB-8040 | biostudies-arrayexpress
UnknownCanonical and non-canonical miRNA degradation shapes state transitions and stemness in breast cancer
Not available
S-SCDT-10_1038-S44318-026-00889-8 | biostudies-other
TranscriptomicsBinary cell fate decision as high-dimensional critical state transition
During commitment of a multipotent stem or progenitor cell to a particular lineage, a large number of genes alter their expression in a coordinated manner orchestrated by the gene regulatory network (GRN). The constraints imposed by the GRN govern how cells move in the high-dimensional gene expressi...
ORGANISM(S): Mus musculus 
2016-09-01 | E-GEOD-70405 | biostudies-arrayexpress
UnknownStructural obstruction to full DNA replication in terminally differentiated skeletal muscle cells
Not available
S-SCDT-10_1038-S44319-025-00554-X | biostudies-other
UnknownAssessment of Ramucirumab plus paclitaxel as switch maintenance versus continuation of first-line chemotherapy in patients with advanced HER-2 negative gastric or gastroesophageal junction cancers: the ARMANI phase III trial.
Not available
S-EPMC6440108 | biostudies-literature
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