Sort   by:  
 Page size 
UnknownEngineering ATP Import in Yeast Uncovers a Synthetic Route to Extend Cellular Lifespan.
Aging results from the gradual accumulation of molecular damage as a result of cellular processes and is characterized by impaired functions, most notably an age-related decline in ATP production. However, the causal relationship between cellular ATP homeostasis and aging has not been established. I...
S-EPMC12667902 | biostudies-literature
ProteomicsThe genome of North American beaver provides insights into the mechanisms of its longevity and cancer resistance
Comparative proteome analysis of beaver (Castor canadensis) and mouse (Mus musculus) liver tissues
ORGANISM(S): Castor canadensis Mus musculus (Mouse) 
2022-02-16 | PXD028546 | Pride
Cancer Longevity Comparative biology Aging 
UnknownA single cell atlas of the mouse seminal vesicle.
During mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive tract and in nourishing sperm for their onwards journey. Along with minor contributions from the prosta...
S-EPMC12060236 | biostudies-literature
UnknownA single cell atlas of the mouse seminal vesicle.
During mammalian reproduction, sperm are delivered to the female reproductive tract bathed in a complex medium known as seminal fluid, which plays key roles in signaling to the female reproductive tract and in nourishing sperm for their onwards journey. Along with minor contributions from the prosta...
S-EPMC11030459 | biostudies-literature
UnknownGenomic expansion of Aldh1a1 protects beavers against high metabolic aldehydes from lipid oxidation.
The North American beaver is an exceptionally long-lived and cancer-resistant rodent species. Here, we report the evolutionary changes in its gene coding sequences, copy numbers, and expression. We identify changes that likely increase its ability to detoxify aldehydes, enhance tumor suppression and...
S-EPMC8656434 | biostudies-literature
UnknownLINE1 Derepression in Aged Wild-Type and SIRT6-Deficient Mice Drives Inflammation.
Mice deficient for SIRT6 exhibit a severely shortened lifespan, growth retardation, and highly elevated LINE1 (L1) activity. Here we report that SIRT6-deficient cells and tissues accumulate abundant cytoplasmic L1 cDNA, which triggers strong type I interferon response via activation of cGAS. Remarka...
S-EPMC6449196 | biostudies-literature
UnknownDNA methylation networks underlying mammalian traits.
Using DNA methylation profiles (n = 15,456) from 348 mammalian species, we constructed phyloepigenetic trees that bear marked similarities to traditional phylogenetic ones. Using unsupervised clustering across all samples, we identified 55 distinct cytosine modules, of which 30 are related to...
S-EPMC11180965 | biostudies-literature
UnknownThe second international conference "genetics of aging and longevity".
Not available
S-EPMC5533612 | biostudies-literature
UnknownDNA repair and anti-cancer mechanisms in the long-lived bowhead whale.
At over 200 years, the maximum lifespan of the bowhead whale exceeds that of all other mammals. The bowhead is also the second-largest animal on Earth, reaching over 80,000 kg1. Despite its very large number of cells and long lifespan, the bowhead is not highly cancer-prone, an incongruit...
S-EPMC11580846 | biostudies-literature
UnknownARDD 2020: from aging mechanisms to interventions.
Aging is emerging as a druggable target with growing interest from academia, industry and investors. New technologies such as artificial intelligence and advanced screening techniques, as well as a strong influence from the industry sector may lead to novel discoveries to treat age-related diseases....
S-EPMC7803558 | biostudies-literature
Sort   by:  
 Page size