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ProteomicsHX-MS study of SHP2, WT and 2 phosphomimic mutants
SHP2 is a phosphatase and a critical mediator of receptor tyrosine kinase (RTK)-driven RAS/mitogen-activated protein kinase (MAPK) signaling. Despite promising preclinical data, SHP2 inhibitors have shown minimal clinical efficacy, with no defined clinical mechanisms of primary resistance. Here, we ...
ORGANISM(S): Homo sapiens (Human) 
2026-01-23 | PXD073482 | Pride
Human Hx-ms Shp2 
ProteomicsA machine learning method for calculating highly localized protein stabilities
The residue-level free energy of opening (∆Gop) is the ultimate thermodynamic descriptor of localized protein stability, providing valuable information about the protein ensemble at physiologically relevant timescales and conditions. PFNet instantly determines ΔGop for arbitrarily large proteins and...
ORGANISM(S): Escherichia phage T4 
2026-04-10 | PXD069693 | Pride
ProteomicsPIGEON-FEATHER datasets, extracting site-resolved energetic information from HX/MS experiments
We present PIGEON-FEATHER, a method for calculating free energies of opening (∆Gop) at single- or near-single-amino acid resolution for protein ensembles of all sizes from hydrogen exchange/mass spectrometry (HX/MS) data. PIGEON-FEATHER disambiguates and reconstructs all experimentally measured isot...
ORGANISM(S): Escherichia coli 
2024-08-06 | PXD054550 | Pride
Ecdhfr Hdhfr Laci Hx/ms 
ProteomicsPIGEON-FEATHER datasets, extracting site-resolved energetic information from HX/MS experiments
We present PIGEON-FEATHER, a method for calculating free energies of opening (∆Gop) at single- or near-single-amino acid resolution for protein ensembles of all sizes from hydrogen exchange/mass spectrometry (HX/MS) data. PIGEON-FEATHER disambiguates and reconstructs all experimentally measured isot...
ORGANISM(S): Escherichia coli 
2024-11-05 | PXD057539 | Pride
Ecdhfr Hdhfr Laci Hx/ms 
ProteomicsDistinct energetic blueprints diversify function of conserved protein folds
While the ongoing revolution in structural biology offers an unprecedented understanding of the relationship between protein structure and function, it also confirms a puzzling, widely applicable principle: protein domains with highly conserved three-dimensional folds can perform radically disparate...
ORGANISM(S): Escherichia coli 
2026-05-25 | PXD062370 | Pride
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