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GenomicsChIP-seq analysis of Gli1 and Sox2 input to neural progenitor program and integration with actve histone marks
In the vertebrate neural tube, regional Sonic hedgehog (Shh) signaling invokes a time- and concentration-dependent induction of six different cell populations mediated through Gli transcriptional regulators. Elsewhere in the embryo, Shh/Gli responses invoke different tissue appropriate regulatory pr...
ORGANISM(S): Mus musculus 
2012-12-15 | E-GEOD-42132 | biostudies-arrayexpress
TranscriptomicsRegulation of GLI underlies a role for BET bromodomains in pancreatic cancer growth and the tumor microenvironment
Pancreatic ductal adenocarcinoma (PDAC) is extraordinarily chemoresistant and the abundant stromal content of these tumors contributes to the ineffective treatment of this disease. While the genetic alterations of PDAC have been well characterized, the epigenetic pathways regulating PDAC remain, fo...
ORGANISM(S): Homo sapiens 
2016-09-08 | E-GEOD-55209 | biostudies-arrayexpress
ProteomicsIdentification of GLI-associated proteins by mass spectrometry
The Hedgehog signaling pathway is essential for the maintenance and response of several types of stem cells. To study the transcriptional response of stem cells to HH signaling, we searched for proteins binding to GLI proteins, the transcriptional effectors of the HH pathway in mouse embryonic stem ...
ORGANISM(S): Mus musculus (Mouse) 
2016-02-04 | PXD002494 | Pride
Nanog Embryonic stem cells Gli Hedgehog signaling 
GenomicsRole of GLI-signaling in the postnatal cardiomyocyte development
Role of GLI-signaling in the postnatal cardiomyocyte development
PRJNA832267 | ENA
TranscriptomicsGene expression analysis in Panc-1 cells in response to treatment with Gli3T, a dominant-negative repressor of Gli
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most aggressive human malignancies. In our studies, we find that the Gli transcription factors are required for Kras initiation of pancreatic tumorigenesis. In order to identify the downstream transcriptional targets of Gli in PDAC, we conducted ...
ORGANISM(S): Homo sapiens 
2012-03-28 | E-GEOD-36855 | biostudies-arrayexpress
TranscriptomicsRNA-seq and ChIP-seq identification of unique and overlapping targets of GLI transcription factors in melanoma cell lines
Despite significant progress in therapy, melanoma is still the most lethal form of skin cancer, with a rising incidence worldwide. Little is known about the impact of deregulated Hedgehog-GLI (HH-GLI) signalling pathway in the progression of this disease. Based on previous research, we hypothesized ...
ORGANISM(S): Homo sapiens 
2023-01-01 | E-MTAB-11936 | biostudies-arrayexpress
GenomicsGLI transcriptional repression is inert prior to HH pathway activation
GLI transcriptional repression is inert prior to HH pathway activation
PRJNA741224 | ENA
GenomicsThe BAF complex does not mediate GLI repression (ATAC-Seq)
The BAF complex does not mediate GLI repression (ATAC-Seq)
PRJNA934433 | ENA
TranscriptomicsTranscription profiling of embryoid bodies treated with retinoic-acid or retinoic-acid + hedgehog agonist to measure neural targets of sonic hedgehog signaling
This experiment was specifically designed to measure neural targets of Shh signaling, we sought to profile the genes upregulated by Hh signaling in the ventral neural tube to obtain a valid dataset. To obtain ventral-specific markers, we generated retinoic acid-treated EBs grown in the presence or ...
ORGANISM(S): Mus musculus 
2007-11-22 | E-GEOD-4936 | biostudies-arrayexpress
TranscriptomicsHedgehog/GLI signalling and hormone independence in prostate cancer (PCa) cell lines
High levels of GLI (GLI1 and GLI2) mRNA and GLI luciferase reporter activity were detected in the androgen independent prostate cancer cell lines DU145 and PC-3 compared to the androgen-dependent LNCaP prostate cancer cell line. Subsequently, we observed that ectopic GLI1 promoted hormone independen...
ORGANISM(S): Homo sapiens 
2011-02-13 | E-GEOD-27231 | biostudies-arrayexpress
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