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MetabolomicsUntargeted LC-MS metabolomics of the cecal contents in gliadin-induced colitis mice

Background: Gliadin, a key dietary antigen in celiac disease and intestinal inflammation, has unclear effects on the local metabolic microenvironment of the gut under colitic conditions. Objective: This study aimed to systematically characterize the metabolic alterations in cecal contents of glia...

2026-08-19 | MTBLS15178 | MetaboLights
TranscriptomicsTranscription profiling by array of human duodenum biopsies from normalized celiac patients treated with gliadin
Study of the effects of re-exposure to gliadin of intestinal biopsies from normalized celiac patients (>2 years on gluten free diet). Comparison of the expresson profile in biopsy portions incubated with 10ug/ml gliadin versus without gliadin for 4 hours.
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1823 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of duodenum biopsies from patients with celiac disease taken at time of diagnosis or after two years of a gluten free diet
Study on the effects of long term, dietary, consumption of gliadin (gluten) in patients with celiac disease. Comparison of expression profiles of biopsies from normalized patients treated with gluten-free diet >2 years (FU-follow-up samples) versus biopsies from patients with active disease (Dx-at d...
ORGANISM(S): Homo sapiens 
2009-06-01 | E-MEXP-1828 | biostudies-arrayexpress
ProteomicsTowards reducing the immunogenic potential of wheat flour: silencing of alpha gliadin genes in a U.S. wheat cultivar
The alpha gliadins are a complex group of proteins with very similar sequences that comprise about 15-20% of the total flour protein and contribute to the functional properties of wheat flour dough. Some alpha gliadins also contain immunodominant epitopes relevant to celiac disease, a chronic autoi...
ORGANISM(S): Triticum aestivum (Wheat) 
2020-02-28 | PXD016930 | Pride
Lc-msms Triticum aestivum Gliadin Wheat Immunogenic 
TranscriptomicsGene expression profile of gliadin effects on intestinal epithelial cells suggests novel non-enzymatic functions of pepsin and trypsin
Gliadin triggers T-cell mediated immunity in celiac disease, and has cytotoxic effects on enterocytes mediated through obscure mechanisms. In addition, gliadin transport mechanisms, potential cell surface receptors and gliadin-activated downstream signaling pathways are not completely understood. In...
ORGANISM(S): Homo sapiens 
2013-03-21 | E-GEOD-45357 | biostudies-arrayexpress
TranscriptomicsTIMP-GLIA (gliadin nanoparticle) treatment in transgenic mice expressing celiac disease associated HLA-DQ8
This submission contains raw data obtained from RNA sequencing of mouse spleen cells. Spleen cells were derived from adult female HLA-DQ8, huCD4 transgenic Ab0 NOD mice, treated intravenously either with tolerogenic, immune-modifying nanoparticles containing gliadin (TIMP-GLIA), particles containing...
ORGANISM(S): Mus musculus 
2019-11-21 | GSE140736 | GEO
TranscriptomicsRapamycin-Gliadin Composite Nanoparticles Enhance Hepato-Splenic Dialogue for Gluten Tolerance in Celiac Disease
Background Celiac disease (CeD) is an autoimmune disorder triggered by gluten, with gliadin as the primary antigen. Therapies targeting gliadin to induce antigen-specific immune tolerance are of significant interest. This study investigates the therapeutic potential of a novel rapamycin-gliadin comp...
ORGANISM(S): Mus musculus 
2025-07-30 | GSE275197 | GEO
GenomicsRapamycin-Gliadin Composite Nanoparticles Enhance Hepato-Splenic Dialogue for Gluten Tolerance in Celiac Disease
Rapamycin-Gliadin Composite Nanoparticles Enhance Hepato-Splenic Dialogue for Gluten Tolerance in Celiac Disease
PRJNA1149773 | ENA
TranscriptomicsGene expression profile of gliadin effects on intestinal epithelial cells suggests novel non-enzymatic functions of pepsin and trypsin
Gliadin triggers T-cell mediated immunity in celiac disease, and has cytotoxic effects on enterocytes mediated through obscure mechanisms. In addition, gliadin transport mechanisms, potential cell surface receptors and gliadin-activated downstream signaling pathways are not completely understood. In...
ORGANISM(S): Homo sapiens 
2013-03-21 | GSE45357 | GEO
GenomicsTIMP-GLIA (gliadin nanoparticle) treatment in transgenic mice expressing celiac disease associated HLA-DQ8
TIMP-GLIA (gliadin nanoparticle) treatment in transgenic mice expressing celiac disease associated HLA-DQ8
PRJNA590711 | ENA
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