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ProteomicsHuman Glioblastoma Cell Line Secretome LC-MS/MS
To investigate the effect of glioblastoma secretome in activating tau pathology, Glioblastoma cell line secretome were prefractionated with gel filtration chromatography. Secretome analyzed by LC-MS/MS and identified targets using PSM count quantitation.
ORGANISM(S): Homo sapiens (Human) 
2018-07-16 | PXD007969 | Pride
Human Brain Glioblastoma 
ProteomicsGBM cell line secretome analysis
Glioblastoma (GBM) is the most common and aggressive brain tumor in adults. The purpose of the present study was to identify GBM cell-selective secreted proteins by analyzing conditioned media (CM) from GBM, breast, and colon cancer cell lines using sequential window acquisition of all theoretical s...
ORGANISM(S): Homo Sapiens (human) 
2020-09-19 | PXD016898 | JPOST Repository
TranscriptomicsRNA-seq of four human glioblastoma cell lines from heterogeneous U-343 cell system
Four glioblastoma cell line U-343 MG, U-343 MGa, U-343 MGa 31L, U-343 MGa Cl2:6 were derived form the same glioblastoma U-343. The RNA-seq was performed to identify their difference and better understand the glioblastoma heterogeneity.
ORGANISM(S): Homo sapiens 
2020-08-10 | E-MTAB-8620 | biostudies-arrayexpress
ProteomicsO-GlcNAcase activity is necessary for the molecular signature of the Glioblastoma secretome
Glioblastoma (GBM) is a grade IV glioma highly aggressive and refractory to the therapeutic approaches currently in use nowadays. Although sugar metabolism through the hexosamine biosynthetic pathway (HBP) plays a key role in tumor aggressiveness and progression in different types of cancer, whether...
ORGANISM(S): Homo sapiens (Human) 
2021-09-09 | PXD019496 | Pride
Glioblastoma secretome Lcms O-glcnacase activity 
OtherQuantitative proteomic analysis reveals effects of EGFR on invasion-promoting proteins secreted by glioblastoma cells.
Data from PeptideAtlas, [[http://www.peptideatlas.org/PASS/PASS00455 PASS00455]]. Experiment: PTEN+EGFR_1, file: folder summary. Published as part of Mol Cell Proteomics. 2014 Jul 5 . From the Abstract: {{i}} ... To better understand how EGFR contributes to tumor aggressiveness, we investigated the...
ORGANISM(S): Homo_sapiens_viruses, Human 
GPM11210028781 | GPMDB
ProteomicsInhibition of the Histone Deacetylase activity impacts on Glioblastoma secretome and disrupts the molecular signature of the Tumor Extracellular Matrix
Glioblastoma (GBM) is the most prevalent primary malignant brain tumor in adults and remains almost invariably lethal due to its aggressive and invasive behavior. Despite many clinical trials have been put forward, the standard treatment that stands for more than a decade consists of surgical resect...
ORGANISM(S): Homo sapiens (Human) 
2024-05-22 | PXD022982 | Pride
Glioblastoma secretome Histone deacetylase activity Lc-ms/ms 
ProteomicsSecretome analysis of glioblastoma cells
PKR-like kinase (PERK) plays a significant role in inducing angiogenesis in various cancer-types including glioblastoma. Mass spectrometry screen on conditioned media from LN308 glioblastoma cell line treated with hypoxia revealed Peptidylglycine α-amidating monooxygenase (PAM) as a potential target...
ORGANISM(S): Homo sapiens (Human) 
2020-03-05 | PXD012523 | Pride
Glioblastoma Perk inhibitor Label-free Secretome Shot-gun proteomics Dda 
ProteomicsUsing a Dual CRISPR/Cas9 Approach to Gain Insight into the Role of LRP1B in Glioblastoma
LRP1B remains one of the most altered genes in cancer, although its relevance in cancer biology is still unclear. Recent advances in gene editing techniques, particularly CRISPR/Cas9 systems, offer new opportunities to evaluate the function of large genes, like LRP1B. Using a dual sgRNA CRISPR/Cas9 ...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD042667 | Pride
Glioblastoma Ploidy Crispr/cas9 Lrp1b Secretome 
UnknownModulation of the blood-brain barrier permeability by patient-derived glioblastoma stem cell secretome.
Not available
S-EPMC12559403 | biostudies-literature
UnknownInterleukin-1-induced changes in the glioblastoma secretome suggest its role in tumor progression.
Not available
S-EPMC3977979 | biostudies-literature
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