Sort   by:  
 Page size 
ProteomicsMouse kidney glomerular extracellular matrix LC-MSMS
Across the spectrum of human disease there are significant changes in the composition and organisation of extracellular matrix (ECM). Furthermore, disease severity can vary according to race and sex, yet mechanisms for these variations are unclear. Using the kidney glomerulus as a model system, we t...
ORGANISM(S): Mus musculus (Mouse) 
2016-07-09 | PXD000811 | Pride
Lc-msms Mouse Kidney Glomerular Extracellular matrix 
ProteomicsInvestigating the effect of fluid flow on glomerular cell-derived matrix
The glomerular basement membrane has a complex composition and structure in vivo. In vitro models of the glomerular capillary wall have been developed using microfluidic and perfusion systems, however, how the extracellular matrix alters under static and flow conditions has not yet been investigate...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD044226 | Pride
Glomerular matrix Microfluidic bioreactor Glomerular filtration barrier 
TranscriptomicsGlomerular transcriptome from subjects in the NEPTUNE cohort
Glomerular Transcriptome from subjects in the NEPTUNE cohort. A number of samples profiled in this analysis were also profiled in Series GSE68127, and Series GSE108113. RNA from the glomerular compartment of was extracted and processed for hybridization on Affymetrix microarrays. Contributor: NEPTU...
ORGANISM(S): Homo sapiens 
2018-05-17 | E-GEOD-104066 | biostudies-arrayexpress
TranscriptomicsIndoxyl sulfate, a uremic toxin and aryl-hydrocarbon receptor ligand, mediates progressive glomerular disease by damaging podocytes
Indoxyl sulfate (IS) is a uremic toxin and ligand of the aryl-hydrocarbon receptor (Ahr), a transcriptional regulator. Elevated serum IS may contribute to the progression of kidney disease. Therefore, we assessed mouse podocyte damage mediated by IS. Ahr was predominantly localized to the podocyte n...
ORGANISM(S): Homo sapiens 
2014-10-14 | E-GEOD-51834 | biostudies-arrayexpress
ProteomicsHuman kidney proteomics, glomerular and tubular cellular and matrix fractions
Glomerular and tubulointerstitial fractions were enriched from human kidneys samples. Ages of human kidney samples: 15, 29, 37, 61, 67 and 69 years of age. The glomerular and tubulointerstitial samples were processed to enrich for extracellular matrix components and the fractions analysed by mass sp...
ORGANISM(S): Homo sapiens (Human) 
2022-02-22 | PXD022219 | Pride
Tubulointerstitial Tubular Glomerular Kidney Age 
TranscriptomicsEverolimus protects podocytes via stabilizing TUBB2B and DCDC2 expression
Glomerular podocytes are highly differentiated cells that are key components of the kidney filtration units. The podocyte cytoskeleton builds the basis for the dynamic podocyte cytoarchitecture and plays a central role for proper podocyte function. Recent studies implicate that immunosuppressive age...
ORGANISM(S): Homo sapiens 
2015-09-09 | E-GEOD-66107 | biostudies-arrayexpress
ProteomicsCol4a1 mouse glomerular datasets
Glomeruli were isolated from Col4a1+/SVC and Ctrl mice. Samples were enriched for extracellular matrix. Glomerular extracellular matrix and cellular fractions were analysed by mass spectrometry.
ORGANISM(S): Mus musculus (Mouse) 
2022-08-12 | PXD022363 | Pride
Matrix fraction Glomerulus Mouse Kidney Col4a1 Cellular fraction 
ProteomicsProteomic analysis of glomerular organoid extracellular matrix
Introduction Points to consider adding: -The matrix in the kidney/glomerulus is specialised and complex with basement membrane structures in addition to interstitial matrix components. -The glomerular basement membrane undergoes change in isoform composition of key matrix components including type I...
ORGANISM(S): Homo sapiens (Human) 
2019-01-03 | PXD012198 | Pride
Ecm Proteomics Mass spectrometry Organoid Glomerulus Matrix 
TranscriptomicsTranscription profiling of 8-day-old Podocin-Cre, Z/EG double transgenic mice glomerulus and brain
Mouse glomeruli and brain capillary fragments were prepared. Podocytes were separated from isolated glomeruli from 8-day-old Podocin-Cre, Z/EG double transgenic mice as follows: Isolated glomeruli were incubated with trypsin solution containing 0.2 % trypsin-EDTA (Sigma-Aldrich), 100ug/ml Heparin an...
ORGANISM(S): Mus musculus 
2006-10-31 | E-MEXP-492 | biostudies-arrayexpress
GenomicsMesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture
Mesangial cell-derived extracellular matrix protein 1 is essential for maintaining mesangial matrix homeostasis and glomerular architecture
PRJNA1336614 | ENA
Sort   by:  
 Page size