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MetabolomicsMetabolomics reveals increased toxicity in earthworms (Eisenia fetida) of the transformation product methyl-triclosan
The effects of the antimicrobial triclosan (TCS) and its transformation product methyl-triclosan (MTCS) on the earthworm Eisenia fetida were investigated using GC-MS metabolomics. TCS is ubiquitous in sewage sludge, but a large proportion is transformed into MTCS during wastewater treatment and in s...
2018-09-17 | MTBLS532 | MetaboLights
MetabolomicsAnalyzing nicotine action against amyloid toxicity by NMR-pharmacometabolomics: an exploratory study

Alzheimer's disease (AD) is the primary neurodegenerative disease spread worldwide. One of the main histopathological hallmarks of AD is amyloid plaque deposition in the brain. Despite some epidemiological studies demonstrating that cigarette smoke is a factor in predisposing people to AD, nicoti...

2026-06-26 | MTBLS12706 | MetaboLights
MetabolomicsMechanism of Trichloroethylene (TCE) toxicity in the placenta
Not available
ORGANISM(S): Homo sapiens 
ST001398 | MetabolomicsWorkbench
MetabolomicsIAPP toxicity activates HIF1α/PFKFB3 signaling delaying β-cell loss at the expense of β-cell function
The islet in type 2 diabetes (T2D) is characterized by amyloid deposits derived from islet amyloid polypeptide (IAPP), a protein co-expressed with insulin by β-cells. In common with amyloidogenic proteins implicated in neurodegeneration, human IAPP (hIAPP) forms membrane permeant toxic oligomers imp...
2020-04-17 | MTBLS951 | MetaboLights
MetabolomicsGlucose potentiates florfenicol killing of antibiotic-resistant V. parahaemolyticus by enhancing proton motive force and reactive oxygen species

 Florfenicol is valued for its clinical safety, particularly its reduced bone marrow toxicity compared to other old antibiotics of chloramphenicols. However, the rise of bacterial resistance threatens its efficacy. To address this, we evolved a florfenicol-resistant strain of Vibrio par...

2025-10-14 | MTBLS13132 | MetaboLights
MetabolomicsMulti-Platform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity (part-I)
Not available
ORGANISM(S): Mus musculus 
ST001007 | MetabolomicsWorkbench
MetabolomicsMulti-Platform Physiologic and Metabolic Phenotyping Reveals Microbial Toxicity (part II)
Not available
ORGANISM(S): Mus musculus 
ST001008 | MetabolomicsWorkbench
TranscriptomicsTranscription profiling of zebrafish ovary treated with the reproductive toxicant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD)
2,3,7,8-TCDD (TCDD) is a reproductive toxicant and endocrine disruptor in nearly all vertebrates, yet the mechanisms by which TCDD induces these reproductive alterations have not been fully characterized. Fish are among the most sensitive vertebrates to the toxic effects of TCDD, and even subtle ph...
ORGANISM(S): Danio rerio 
2009-04-30 | E-GEOD-4859 | biostudies-arrayexpress
TranscriptomicsEffect of insulin infusion on human skeletal muscle
To identify insulin responsive genes in humans, in the first protocol, skeletal muscle biopsies from six non-diabetic subjects were obtained before and after a two-hour of hyperinsulinaemic (infusion rate 40 mU/m2/min) euglycemic clamp. A variable infusion of glucose (180 g/l) enriched with tritiate...
ORGANISM(S): Homo sapiens 
2007-03-01 | E-GEOD-7146 | biostudies-arrayexpress
TranscriptomicsEffect of pH on Cadmium Toxicity in Escherichia coli
Metals at high concentrations can exert toxic effects on microorganisms. It has been widely reported that lowering environmental pH reduces effects of cadmium toxicity in bacteria. Understanding the effects of pH-mediated cadmium toxicity on bacteria would be useful for minimizing cadmium toxicity...
ORGANISM(S): Escherichia coli str. K-12 substr. MG1655 
2008-08-21 | E-GEOD-12373 | biostudies-arrayexpress
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