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ProteomicsDynamic changes in proteome and phosphoproteome following glutamate excitotoxicity in cultured primary cortical neurons
Excitotoxicity caused by over-stimulation of the ionotropic glutamate receptors is a key neuronal cell death process underpinning brain damage in acute and chronic neurological disorders such as ischaemic stroke, traumatic brain injury, and neurodegenerative diseases. Exactly how neurons die in exci...
ORGANISM(S): Mus musculus (Mouse) 
2019-03-07 | PXD008353 | Pride
Neuron Phosphoproteome Proteome Excitotoxicity 
TranscriptomicsA SUMOylated C-terminus fragment of glutamate transporter EAAT2 linked to inherited ALS mediates motor axon impairment
Downregulation of expression and activity levels of the astroglial glutamate transporter EAAT2 is thought to be implicated in motor neuron excitotoxicity in amyotrophic lateral sclerosis (ALS). We previously reported that EAAT2 is cleaved by caspase-3 at the cytosolic C-terminus domain, impairing th...
ORGANISM(S): Mus musculus 
2011-07-19 | E-GEOD-26070 | biostudies-arrayexpress
TranscriptomicsGlobal gene profiling of glutamate-induced neuronal death
Glutamate, a major neurotransmitter in the mammalian nervous sytem, has been involved in the mediation of excitotoxicity commonly observed in the pathogenesis of stroke. Current study focused on gaining an insight into the molecular mechanisms of glutamate-induced neuronal death A total of 15 RNA sa...
ORGANISM(S): Mus musculus 
2013-12-31 | E-GEOD-19936 | biostudies-arrayexpress
ProteomicsPterosin B treatment protect cells from glutamate-induced cytotoxicity
The prevalence of neurodegenerative diseases is rapidly increasing with the aging trend of global populations, severely threatening human health and burdening society. However, to date, there is no effective treatment able to halt the progression or cure the diseases. Here, We aim to develop effecti...
ORGANISM(S): Mus musculus (Mouse) 
2023-03-01 | PXD030396 | Pride
Ros Neuroprotective natural products Glutamate excitotoxicity Mitochondria membrane potential 
ProteomicsN-terminomics Analysis of Mouse cultured cortical neuron during excitotoxicity
Excitotoxicity is a primary pathological process directing neuronal cell death in both acute neurological disorders and neurodegenerative diseases such as ischemic stroke and Alzheimer’s disease. We use mouse cultured cortical neuron treated with 100uM of Glutamate for a model of excitotoxicity and ...
ORGANISM(S): Mus musculus (Mouse) 
2023-04-07 | PXD040648 | Pride
N-term Excitotoxicity 
GenomicsNeuroprotective effect of secreted factors from glial progenitor cells in a model of glutamate excitotoxicity
Neuroprotective effect of secreted factors from glial progenitor cells in a model of glutamate excitotoxicity
PRJNA1187455 | ENA
UnknownDopamine protects neurons against glutamate-induced excitotoxicity.
Not available
S-EPMC3563982 | biostudies-literature
UnknownNeuroprotection by Mitochondrial NAD Against Glutamate-Induced Excitotoxicity.
Not available
S-EPMC12025592 | biostudies-literature
GenomicsKinomic analysis of excitotoxicity in primary neuronal cultures
Kinomic analysis of excitotoxicity in primary neuronal cultures
PRJNA1073411 | ENA
TranscriptomicsKinomic analysis of excitotoxicity in primary neuronal cultures
Glutamate excitotoxicity plays a critical role in neurodegeneration by triggering NMDA receptorhyperactivation, leading to elevated synaptic calcium levels and subsequent neuronal cell death. Tobetter understand how glutamateaffects neurons in neurological diseases, we conducted acomprehensive analy...
ORGANISM(S): Rattus norvegicus 
2024-05-28 | GSE255041 | GEO
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