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ProteomicsOuter membrane utilisomes mediate oligosaccharide uptake in gut Bacteroidetes
Bacteroidetes are abundant members of the human microbiota, and species occupying the distal gut are capable of utilising a myriad of diet- and host-derived glycans. Transport of glycans across the outer membrane (OM) of these bacteria is mediated by SusCD protein complexes. Additionally, cell surfa...
ORGANISM(S): Bacteroides thetaiotaomicron Bacteria 
2023-06-19 | PXD034863 | Pride
Outer membrane proteome Microbiota Glycan utilisation Gut bacteroidetes 
ProteomicsOpen database searching enables the identification and comparison of glycoproteomes without defining glycan compositions prior to searching
Mass spectrometry has become an indispensable tool for the characterisation of glycosylation across biological systems. Our ability to generate rich fragmentation data of glycopeptides has dramatically improved over the last decade yet our informatic approaches still lag be hide. This is especially ...
ORGANISM(S): Campylobacter fetus subsp. fetus Burkholderia cenocepacia J2315 Burkholderia pseudomallei (strain K96243) Acinetobacter baumannii 
2020-06-24 | PXD018587 | Pride
Wide tolerant database searching Bacterial glycosylation Open searching Glycosylation Glycopeptides Post-translational modifications Proteomics Atypical glycosylation 
UnknownUtilisation of mucin glycans by the human gut symbiont Ruminococcus gnavus is strain-dependent.
Not available
S-EPMC3808388 | biostudies-literature
TranscriptomicsAssigning a role for chemosensory signal transduction in Campylobacter jejuni biofilms using a combined omics approach
Biofilms serve as a protective mechanism for bacteria to cope with environmental stress. Whilst ordinarily a fastidious organism, it has been long suggested that C. jejuni is able to utilise this mode of growth as a way to transmit infection from the avian host to humans. Herein, we undertook a comb...
ORGANISM(S): Campylobacter jejuni 
2019-07-04 | GSE133783 | GEO
TranscriptomicsIntegrated microbiome and host profiling in a mouse model of colitis suggests host immune activity drives changes in the gut micro-environment that influence both microbial community structure and gene expression
The gut microbiome is significantly altered in inflammatory bowel diseases, but the basis of these changes is not well understood. We have combined metagenomic and metatranscriptomic profiling of the gut microbiome to assess changes to both bacterial community structure and transcriptional activity ...
ORGANISM(S): Mus musculus 
2015-05-22 | E-MTAB-3590 | biostudies-arrayexpress
GenomicsIntegrated microbiome and host profiling in a mouse model of colitis suggests host immune activity drives changes in the gut micro-environment that influence both microbial community structure and gene expression
The gut microbiome is significantly altered in inflammatory bowel diseases, but the basis of these changes is not well understood. We have combined metagenomic and metatranscriptomic profiling of the gut microbiome to assess changes to both bacterial community structure and transcriptional activity ...
ORGANISM(S): Mus musculus 
2015-05-22 | E-MTAB-3562 | biostudies-arrayexpress
UnknownCarbohydrates and carbohydrate degradation gene abundance and transcription in Atlantic waters of the Arctic.
Not available
S-EPMC10710508 | biostudies-literature
TranscriptomicsRNA-seq of Candida albicans SC5314 grown on minimal media supplemented with glucose or inulin preparations
Changes in carbon source influence genome-wide gene expression in Candida albicans, thereby modulating key virulence traits such as adhesion, morphogenesis, and stress resistance. To investigate the biological consequences of alternative nutrient utilisation, this experiment examined how growth on i...
ORGANISM(S): Candida albicans 
2026-04-29 | E-MTAB-15594 | biostudies-arrayexpress
ProteomicsAn endo-acting galactanase with a type II signal peptide confers keystone status to arabinogalactan degrading bacteria of the human gut microbiota
Glycans, the major source of energy for the human gut microbiota (HGM), are metabolised by numerous members of the Bacteroides genus. Arabinogalactan proteins (AGPs) are a ubiquitous and highly heterogenous group of plant glycans in which a B1,3-galactan backbone and B1,6-galactan side chains are co...
ORGANISM(S): Bacteroides thetaiotaomicron (strain ATCC 29148 / DSM 2079 / NCTC 10582 / E50 / VPI-5482) Bacteroides cellulosilyticus 
2018-07-03 | PXD010274 | Pride
Glycan degradation Keystone organism Gut microbiota 
ProteomicsSuccession of Bifidobacterium longum strains in response to a changing early life nutritional environment reveals dietary substrate adaptations
Diet-microbe interactions play a crucial role in infant development and modulation of the early-life microbiota. The genus Bifidobacterium dominates the breast-fed infant gut, with strains of B. longum subsp. longum (B. longum) and B. longum subsp. infantis (B. infantis) particularly prevalent withi...
ORGANISM(S): Bifidobacterium longum subsp. longum 
2020-07-15 | PXD017277 | Pride
Cellobiose Bifidobacterium 2'fucosyllactose Lactoneotetraose 
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