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GenomicsGlyoxal as alternative fixative for single cell transcriptome experiments
Glyoxal as alternative fixative for single cell transcriptome experiments
PRJNA687391 | ENA
ProteomicsGlyoxal induces senescence of human keratinocytes through oxidative stress and activation of the AKT/FOXO3a/p27KIP1 pathway
Senescence is a well-known cellular event characterized by specific markers like a permanent cell proliferation arrest and the secretion of messenger molecules forming the Senescence-Associated Secretory Phenotype (SASP). The SASP composition depends on many factors such as the cell type or the natu...
ORGANISM(S): Homo sapiens (Human) 
2022-01-03 | PXD025184 | Pride
Sasp Keratinocytes Advanced glycation end products Cellular senescence Glyoxal Oxidative stress Dicarbonyl stress Secretory phenotype 
TranscriptomicsGlyoxal as alternative fixative for single cell transcriptome experiments
Within just a few years single cell RNA sequencing has become a frequently used standard method in many research fWithin just a few years single cell RNA sequencing has become a frequently used standard method in many research facilities worldwide. Declining sequencing costs and further refinements ...
ORGANISM(S): Drosophila melanogaster Homo sapiens 
2021-06-22 | GSE163736 | GEO
ProteomicsGlyoxal response in Pseudomonas aeruginosa
The protein Aldehyde responsive quorum-sensing Inhibitor (ARQL) was exposed to increasing levels of glyoxal, to identify the glycation modifications.
ORGANISM(S): Pseudomonas Aeruginosa (ncbitaxon:287) 
2024-02-29 | MSV000094205 | MassIVE
ProteomicsMapping sites of carboxymethyllysine modification on proteins reveals consequences for proteostasis and cell proliferation
Posttranslational mechanisms play a key role in modifying the abundance and function of cellular proteins. Among these, modification by advanced glycation end products (AGEs) has been shown to accumulate during aging and age-associated diseases but specific protein targets and functional consequence...
ORGANISM(S): Homo sapiens (Human) 
2021-11-25 | PXD027468 | Pride
Heart Acetylation Mass spectrometry Tubulin Kidney Mice Endothelial cell Cell cycle Microtubules Advanced glycation end products Carboxymethyllysine Mitosis Liver Glyoxal Proteasome Aging Posttranslational modification 
TranscriptomicsStraightforward extraction of high-quality RNA from glyoxal-fixed cells facilitates transcriptome analysis after cell staining and sorting by flow cytometry
We have developed a methodology for isolation of high-quality RNA from cells that are fixed, stained and sorted by flow cytometry that allows routine transcriptomic analysis of highly purified cell populations and single cells. This method, essentially developed by modifying existing staining and so...
ORGANISM(S): Homo sapiens 
2020-09-30 | GSE158177 | GEO
UnknownGlyoxal in hyperglycaemic ischemic stroke - a cohort study.
Not available
S-EPMC10339542 | biostudies-literature
Genomics
The transcriptional response of Pseudomonas aeruginosa to glyoxal
PRJNA1256497 | ENA
GenomicsStraightforward extraction of high-quality RNA from glyoxal-fixed cells facilitates transcriptome analysis after cell staining and sorting by flow cytometry
Straightforward extraction of high-quality RNA from glyoxal-fixed cells facilitates transcriptome analysis after cell staining and sorting by flow cytometry
PRJNA664206 | ENA
UnknownGlyoxal as an alternative fixative for single-cell RNA sequencing.
Not available
S-EPMC10542564 | biostudies-literature
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