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TranscriptomicsMolecular anatomy of gene expression responses in stressed hepatocytes
It is well-known that isolation and cultivation of primary hepatocytes causes major gene expression alterations. In the present genome-wide, time resolved study of cultivated human and mouse hepatocytes, we made the observation that expression changes in culture strongly resemble alterations in live...
ORGANISM(S): Mus musculus 
2016-09-28 | E-MTAB-4444 | biostudies-arrayexpress
TranscriptomicsTranscriptional responses in liver upon acute CCl4 intoxication
Since xenobiotics enter the organism via the liver, hepatocytes must cope with numerous perturbations. In particular, exposure to hepatotoxic agents resulting in liver injury triggers a strong alteration in gene expression. The contribution of these transcriptional regulatory networks to the propaga...
ORGANISM(S): Mus musculus 
2014-08-31 | E-MTAB-2445 | biostudies-arrayexpress
TranscriptomicsTranscriptomic profiling of mutant and WT HNF4alpha hepatic progenitor stage cells
During mammalian development, liver differentiation is driven by signals which converge on multiple transcription factor networks. The hepatocyte nuclear factor signalling network is known to be essential for hepatocyte specification and maintenance. In these studies we demonstrate that nuclear HNF4...
ORGANISM(S): Homo sapiens 
2019-10-31 | E-MTAB-7951 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells in matrigel and recombinant laminins
Stem cell derived somatic cells represent an unlimited resource for basic and translational science. While promising, there are significant hurdles that must be overcome. Our focus is on the generation of the major cell type of the human liver, the hepatocyte. Current protocols produce variable pop...
ORGANISM(S): Homo sapiens 
2016-01-18 | E-MTAB-3994 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control
Microarray analysis of gene expression regulation in LS174T cells transduced with either ERK-dimerization inhibitory peptide or control.
ORGANISM(S): Homo sapiens 
2020-02-03 | E-MTAB-8111 | biostudies-arrayexpress
TranscriptomicsMicroarray analysis of gene expression regulation in murine hearts treated with an ERK-dimerization inhibitory peptide gene therapy or control after transverse aortic constriction
This study identifies gene expression changes in murine hearts after TAC surgery and in response to gene therapy with ERK-dimerization inhibitory peptide
ORGANISM(S): Mus musculus 
2020-02-03 | E-MTAB-8110 | biostudies-arrayexpress
TranscriptomicsGene expression profile of human embryonic stem cell-derived hepatocyte-like cells
The differentiation of pluripotent stem cells to hepatocyte-like cells offers the perspective of unlimited supply of human hepatocytes. However, the degree of differentiation of hepatic-like cells (HLC) remains controversial. To obtain an unbiased characterization, we performed a transcriptomics st...
ORGANISM(S): Homo sapiens 
2016-02-24 | E-MTAB-4442 | biostudies-arrayexpress
MetabolomicsCoupled Mass-Spectrometry-Based Lipidomics Machine Learning Approach for Early Detection of Clear Cell Renal Cell Carcinoma

A discovery-based lipid profiling study of serum samples from a cohort that included patients with clear cell Renal Cell Carcinoma (ccRCC) stage I, II, III, and IV (n=112) and controls (n=52) was performed using ultraperformance liquid chromatography coupled to quadrupole-time-of-flight mass spec...

2020-11-20 | MTBLS1839 | MetaboLights
UnknownRelationship Between Severity of Ischemia and Coronary Artery Disease for Different Stress Test Modalities in the ISCHEMIA Trial.
Not available
S-EPMC11658795 | biostudies-literature
UnknownInitial Invasive or Conservative Strategy for Stable Coronary Disease.
Not available
S-EPMC7263833 | biostudies-literature
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