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TranscriptomicsTranscriptome of the liver in 15-day-old C3H/HeJ mice
Male C3H/HeOuJ mice are susceptible to spontaneous liver neoplasms. We collected liver samples from young, tumour-free mice for control experiments. Liver tissue samples were snap frozen in liquid nitrogen and total RNA was extracted using the AllPrep 96 DNA/RNA Kit (Qiagen) according to the manufac...
ORGANISM(S): Mus musculus 
2018-07-29 | E-MTAB-6972 | biostudies-arrayexpress
TranscriptomicsWhole-transcriptome of the liver in 15-day-old C3H/HeOuJ and CAST/EiJ mice.
Male C3H/HeOuJ and CAST/EiJ mice were treated with diethylnitrosamine to induce liver tumours. We collected liver samples from untreated P15 mice for control experiments. Liver tissue samples were snap frozen in liquid nitrogen and total RNA was extracted using the AllPrep 96 DNA/RNA Kit (Qiagen) ac...
ORGANISM(S): Mus musculus 
2020-06-18 | E-MTAB-8518 | biostudies-arrayexpress
TranscriptomicsTranscriptome profiles of C3H/HeJ mouse liver tumours
Male C3H/HeOuJ mice are susceptible to spontaneous liver neoplasms. We aged a cohort of mice for up to 76 weeks and isolated liver tumours. Tumours were bisected: one half was snap frozen in liquid nitrogen for RNA extraction and the other half of the tumour was processed for histological examinatio...
ORGANISM(S): Mus musculus 
2018-07-29 | E-MTAB-6971 | biostudies-arrayexpress
TranscriptomicsMolecular profiling of Ctcf hemizygous mouse embryonic fibroblasts: RNA-seq
CTCF is a highly conserved and ubiquitously expressed protein involved in several fundamental processes such as fine-tuning gene expression, imprinting, X-chromosome inactivation and 3D chromatin organisation. To understand the impact of differences in the concentration of CTCF abundance on these pr...
ORGANISM(S): Mus musculus 
2018-07-29 | E-MTAB-6259 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli MG1655 treated with serine hydroxamate
For over 30 years, serine hydroxamate has been used to chemically stimulate a stringent response in Escherichia coli and other bacteria. These studies have elucidated numerous characteristics of the classical stringent response beyond the simple cellular response to an amino acid shortage, including...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17506 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of E. coli high-cell-density recombinant and wild-type
The transcriptome profiles for wild-type (plasmid-free) and recombinant (plasmid-bearing) Escherichia coli during well-controlled synchronized high-cell-density fed-batch cultures were analyzed by DNA microarrays. It was observed that the growth phase significantly affected the transcriptome profile...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17505 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of recombinant E. coli to heat-shock and dual heat-shock recombinant protein induction
Recombinant Escherichia coli cultures are used to manufacture numerous therapeutic proteins and industrial enzymes, where many of these processes use elevated temperatures to induce recombinant protein production. The heat-shock response in wild-type E. coli has been well studied. In this study, t...
ORGANISM(S): Escherichia coli 
2009-08-25 | E-GEOD-17507 | biostudies-arrayexpress
TranscriptomicsRole of PML in repression of transposable elements and in embryonic stem cell fate
RNA-seq analysis from 2 Pml-/- and 3 Pml+/+ mESC samples
ORGANISM(S): Mus musculus 
2022-02-01 | E-MTAB-10153 | biostudies-arrayexpress
TranscriptomicsRNA-seq of human primary epithelial nasal cells infected with SARS-CoV-2 (20A clade) and treated with long chain inorganic polyphosphates (polyP120) against vehicle-(saline solution)- treated controls
Primary human nasal epithelial cells collected by nasal brushing of healthy donors (data deposited at: EVA- EMBL-EBI; project ID: PRJEB42411; analyses: ERZ1700617) were plated (3x105 cells) and infected with SARS-CoV-2 viral particles 20A (EPI_ISL_514432-S66; MOI, 0.03). After 24 hours, the infected...
ORGANISM(S): Homo sapiens 
2024-05-31 | E-MTAB-13363 | biostudies-arrayexpress
TranscriptomicsRejuvenation of pluripotent stem cells by frequent activation of Zscan4, Part A
The gold standard for examining pluripotency of stem cells is to see whether cells can contribute to entire body of animals. Here we show that the increased frequency of Zscan4 activation in mouse ES cells not only enhances, but also maintains their developmental potency in long-term cell culture. A...
ORGANISM(S): Mus musculus 
2013-06-12 | E-GEOD-15604 | biostudies-arrayexpress
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