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GenomicsRBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis
RBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis
PRJNA737638 | ENA
ProteomicsIRE1-dependent GOLIM4 expression controls protein secretion to modulate glioblastoma cell adhesion and migration.
. In the present study, we investigated if and how IRE1 could regulate the functionality of the secretory machinery in GB cells and identified GOLIM4, a Golgi-associated molecule whose expression is regulated downstream of IRE1 through the transcription of XBP1s.
ORGANISM(S): Homo sapiens (Human) 
2026-03-02 | PXD074925 | Pride
Ire1 Golim4 Glioblastoma Secretome 
GenomicsEffects of GOLIM4 knockdown on gene expression in H520 lung cancer cells
Effects of GOLIM4 knockdown on gene expression in H520 lung cancer cells
PRJNA997262 | ENA
UnknownRBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis.
Not available
S-EPMC8373120 | biostudies-literature
TranscriptomicsRBFOX2/GOLIM4 Splicing Axis Activates Vesicular Transport Pathway to Promote Nasopharyngeal Carcinogenesis
ABSTRACT 20-30% of patients with nasopharyngeal carcinoma (NPC) develop distant metastasis or recurrence leading to poor survival, of which the underlying key molecular events have yet to be addressed. Here we profiled alternative splicing events in 85 NPC samples using transcriptome analysis and re...
ORGANISM(S): Homo sapiens 
2022-06-01 | GSE178195 | GEO
TranscriptomicsEffects of GOLIM4 knockdown on gene expression in H520 lung cancer cells
The enhanced Golgi secretory pathway is increasingly recognized as a key driver of cancer progression. GOLIM4, a frequently amplified gene in human cancers, has been implicated in promoting tumor growth and metastasis by enhancing the secretion of oncogenic proteins. To gain further insights into th...
ORGANISM(S): Homo sapiens 
2024-06-04 | GSE237935 | GEO
UnknownMiR-105-3p acts as an oncogene to promote the proliferation and metastasis of breast cancer cells by targeting GOLIM4.
Not available
S-EPMC7962220 | biostudies-literature
UnknownGolgi integral membrane protein 4 manipulates cellular proliferation, apoptosis, and cell cycle in human head and neck cancer.
Not available
S-EPMC6117616 | biostudies-literature
UnknownChromosomal 3q amplicon encodes essential regulators of secretory vesicles that drive secretory addiction in cancer.
Not available
S-EPMC11178546 | biostudies-literature
UnknownRole of the AP-5 adaptor protein complex in late endosome-to-Golgi retrieval.
Not available
S-EPMC5806898 | biostudies-literature
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