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ProteomicsProteome-wide identifying site non-specific cross-linking peptides with SpotLink
We developed SpotLink to identify site non-specific cross-links from the proteome scale. Here described the Abeta dataset and the HeLa dataset to evaluate SpotLink.
ORGANISM(S): Homo sapiens (Human) 
2022-08-25 | PXD030274 | Pride
Spotlink Cross-linking Cx-ms Site non-specific Cl-ms Proteome 
ProteomicsAnalysis of Nucleocytoplasmic Protein Separation in DPST-Crosslinked Human Neuroblastoma SY5Y Cells
Following DPST crosslinking of human neuroblastoma cells, nuclear-cytoplasmic fractionation was performed using hypotonic lysis to obtain cytoplasmic and nuclear protein compartments. Through systematic analysis of crosslinking mass spectrometry data, we elucidated how subcellular compartmentalized ...
ORGANISM(S): Homo Sapiens 
PXD062913 |
ProteomicsOrthogonal Ionic Liquid-based Extraction Strategy Enables Amyloid-Specific Profiling of the Aggregate Proteome
Amyloid deposits are key pathological features of neurodegenerative diseases, yet their structural heterogeneity coupled with a stable β-sheet fibrillar architecture makes them extremely insoluble and difficult to isolate. Through systematic screening and molecular dynamics simulations, we identifie...
ORGANISM(S): Mus Musculus 
PXD069689 |
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