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ProteomicsN7-methylguanosine methylation of tRNAs regulates survival to stress in cancer
Combining transcriptome-wide approaches to detect m7G RNA methylation, in vitro functional assays and Mettl1 knockout mouse models, we provide evidence that guanosine-7 tRNA methylation is required to protect tRNAs from cleavage in response to stress, leading to impaired regulation of protein synthe...
ORGANISM(S): Mus musculus (Mouse) 
2024-01-26 | PXD036009 | Pride
Autophagy 7-methylguanosine Synthetic lethality. Prostate cancer Survival Trna fragments Epitranscriptome Senescence Cytotoxic stress 
ProteomicsMacrophage responses to persistent Borrelia burgdorferi stimulation modulates host inflammation and results in tissue-wide transcriptional and proteomic changes during Lyme carditis
Lyme carditis is an extracutaneous manifestation of Lyme disease characterized by episodes of atrioventricular block of varying degrees and other less reported cardiomyopathies. The molecular changes associated with the response to Borrelia burgdorferi over the course of infection are poorly underst...
ORGANISM(S): Mus musculus (Mouse) 
2021-09-09 | PXD019605 | Pride
Lyme carditis Heart Borrelia burgdorferi Inflammation Macrophages Orbitrap 
ProteomicsGuanosine-7 tRNA methylation steers tRNA-derived fragment biogenesis and translational control in prostate cancer
Transfer RNAs (tRNAs) are exceptionally subject to modifications, including methylation. While mRNA methylation is emerging as an important regulator of biological and pathological processes in cancer, how post-transcriptional methylation of tRNAs contributes to cancer is largely unknown. Here we sh...
ORGANISM(S): Homo sapiens (Human) 
2023-10-24 | PXD030141 | Pride
Cancer Rna modifications 7-methylguanosine Prostate cancer Trnas Trna fragments Epitranscriptome Protein synthesis Translatome 
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