Sort   by:  
 Page size 
MetabolomicsSelective profiling of translationally active tRNAs and their dynamics under stress

During translation, transfer RNAs (tRNAs) deliver specific amino acids to the ribosome in a coordinated manner with the sequence encoded by the mRNA. Despite their central role in protein synthesis, the precise contribution of tRNAs to the modulation of translation remains poorly understood, prim...

2026-06-25 | MTBLS12806 | MetaboLights
TranscriptomicstRNAs marked with CCACCA are targeted for degradation
The CCA-adding enzyme adds CCA to the 3' ends of transfer RNAs (tRNAs), a critical step in tRNA biogenesis that generates the amino acid attachment site. We found that the CCA-adding enzyme plays a key role in tRNA quality control by selectively marking unstable tRNAs and tRNA-like small RNAs for de...
ORGANISM(S): Saccharomyces cerevisiae 
2011-11-17 | E-GEOD-33756 | biostudies-arrayexpress
ProteomicsEfficient Suppression of Premature Termination Codons by Engineered Chimeric Pyrrolysine tRNAs
Mutations that introduce premature termination codons (PTCs) within protein-coding genes are associated with incurable and severe genetic diseases. Many PTC-associated disorders are life-threatening and have no approved medical treatment options. Suppressor transfer RNAs (sup-tRNAs) with the capacit...
ORGANISM(S): Homo sapiens (Human) 
2025-05-06 | PXD044548 | Pride
Suppressor transfer rnas (sup-trnas) Premature termination codons (ptcs) Pyrrolysine trna scaffold suppressor-trnas (pass-trnas) 
ProteomicsIdentification of nascent peptides of peptidyl-tRNA dissociated from ribosome in the early elongation stage in Escherichia coli pthts cells
Accurate translation of mRNAs into functional proteins is a fundamental process in all living organisms. In bacteria, in the early stage of translation elongation, peptidyl-tRNAs (pep-tRNAs) with short nascent chains frequently dissociate from the ribosome (pep-tRNA drop-off). The dissociated pep-tR...
ORGANISM(S): Escherichia coli 
2023-05-18 | PXD030807 | Pride
Translation 
ProteomicsIdentification of nascent peptides of peptidyl-tRNA dissociated from ribosome in the early elongation stage in Escherichia coli pthts cells
Accurate translation of mRNAs into functional proteins is a fundamental process in all living organisms. In bacteria, in the early stage of translation elongation, peptidyl-tRNAs (pep-tRNAs) with short nascent chains frequently dissociate from the ribosome (pep-tRNA drop-off). The dissociated pep-tR...
ORGANISM(S): Escherichia coli 
2023-05-18 | PXD030808 | Pride
Translation 
ProteomicsA method to enrich polypeptidyl-tRNAs to capture snapshots of translation in the cell
Analysis of the peptides obtained from peptidyl-tRNA fraction. Peptidyl-tRNAs were purified by a new method, named PETEOS.
ORGANISM(S): Escherichia Coli 
2023-01-31 | PXD033726 | JPOST Repository
ProteomicsIdentification of nascent peptides of peptidyl-tRNA dissociated from ribosome in the early elongation stage in Escherichia coli pthts cells
Accurate translation of mRNAs into functional proteins is a fundamental process in all living organisms. In bacteria, in the early stage of translation elongation, peptidyl-tRNAs (pep-tRNAs) with short nascent chains frequently dissociate from the ribosome (pep-tRNA drop-off). The dissociated pep-tR...
ORGANISM(S): Escherichia coli 
2023-05-18 | PXD030806 | Pride
Translation 
ProteomicsIdentification of nascent peptides of peptidyl-tRNA dissociated from ribosome in the early elongation stage in Escherichia coli pthts cells
Accurate translation of mRNAs into functional proteins is a fundamental process in all living organisms. In bacteria, in the early stage of translation elongation, peptidyl-tRNAs (pep-tRNAs) with short nascent chains frequently dissociate from the ribosome (pep-tRNA drop-off). The dissociated pep-tR...
ORGANISM(S): Escherichia coli 
2023-05-18 | PXD030805 | Pride
Translation 
GenomicsSmall RNA sequencing of in vitro Angiogenin-hydrolyzed tRNAs
Small RNA sequencing of in vitro Angiogenin-hydrolyzed tRNAs
PRJNA777275 | ENA
ProteomicsMETTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs
A subset of eukaryotic tRNAs is methylated in the anticodon loop to form the 3-methylcytosine (m3C) modification. In mammals, the number of tRNAs containing m3C has expanded to include mitochondrial (mt) tRNA-Ser-UGA and mt-tRNA-Thr-UGU. Whereas the enzymes catalyzing m3C formation in nuclear-encode...
ORGANISM(S): Homo sapiens (Human) 
2022-05-19 | PXD030418 | Pride
Trna modification 3-methylcytosine Trna Mitochondria Mettl8 M3c 
Sort   by:  
 Page size