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ProteomicsCalpain activity is regulated by a KCTD7–cullin 3 complex via non-degradative ubiquitination
Calpains are a class of non-lysosomal cysteine proteases that exert their regulatory functions via limited proteolysis of their substrates. Similar to the lysosomal and proteasomal systems, calpain dysregulation is implicated in the pathogenesis of neurodegenerative disease and cancer. Despite inten...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038842 | Pride
Human Pasef Calpain 
ProteomicsSPT6 functions in transcriptional pause/release via PAF1C recruitment
In vitro studies identified various factors including P-TEFb, SEC, SPT6, PAF1, DSIF, and NELF functioning at different stages of transcription elongation driven by RNA polymerase II (RNA Pol II). What remains unclear is how these factors cooperatively regulate pause/release and productive elongation...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD033771 | Pride
Human Spt6 Paf1c 
UnknownNormalization of NAD+ Redox Balance as a Therapy for Heart Failure.
Not available
S-EPMC5193133 | biostudies-literature
UnknownSPT6 functions in transcriptional pause/release via PAF1C recruitment.
Not available
S-EPMC9714687 | biostudies-literature
UnknownCalpain activity is negatively regulated by a KCTD7-Cullin-3 complex via non-degradative ubiquitination.
Not available
S-EPMC10038992 | biostudies-literature
UnknownDevelopment of a [89Zr]Zr-labeled Human Antibody using a Novel Phage-displayed Human scFv Library.
Not available
S-EPMC10984770 | biostudies-literature
UnknownGlobal Analysis and Comparison of the Transcriptomes and Proteomes of Group A Streptococcus Biofilms.
Not available
S-EPMC5141267 | biostudies-literature
UnknownSPT5 stabilization of promoter-proximal RNA polymerase II.
Not available
S-EPMC8687145 | biostudies-literature
UnknownCord blood proteomics identifies biomarkers of early-onset neonatal sepsis.
Not available
S-EPMC12288901 | biostudies-literature
UnknownAn Antibody Biomarker Associated with Onchocerca volvulus Microfilariae Identified by Proteomic Analysis of Parasite Tissues Isolated from Paraffin Embedded O. volvulus Nodules by Laser Capture Microdissection.
Not available
S-EPMC12403327 | biostudies-literature
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