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TranscriptomicsPaf1C plays novel subunit-specific roles in alternative cleavage and polyadenylation
The PAF complex (Paf1C) has been shown to regulate chromatin modifications, gene transcription, and PolII elongation. Here, we provide the first genome-wide analysis of chromatin occupancy by the entire PAF complex in mammalian cells. We show that Paf1C is recruited not only to promoters and gene bo...
ORGANISM(S): Mus musculus 
2016-01-15 | E-GEOD-72574 | biostudies-arrayexpress
ProteomicsSPT6 functions in transcriptional pause/release via PAF1C recruitment
In vitro studies identified various factors including P-TEFb, SEC, SPT6, PAF1, DSIF, and NELF functioning at different stages of transcription elongation driven by RNA polymerase II (RNA Pol II). What remains unclear is how these factors cooperatively regulate pause/release and productive elongation...
ORGANISM(S): Homo sapiens (Human) 
2022-08-09 | PXD033771 | Pride
Human Spt6 Paf1c 
ProteomicsUbiquitin-dependent transfer of PAF1c from MYC onto RNA Polymerase controls double-strand break repair at active promoters
MYC family proteins are oncogenic transcription factors that can globally affect the function of RNA Polymerase II (RNAPII). The ability of MYC proteins to promote transcription elongation depends on their ubiquitination, but the underlying mechanism and its biological relevance are unknown. Here we...
ORGANISM(S): Homo sapiens (Human) 
2021-02-15 | PXD023242 | Pride
Dna repair Rnapii Myc Paf1c Huwe1 
UnknownArchitecture of the RNA polymerase II-Paf1C-TFIIS transcription elongation complex.
Not available
S-EPMC5467213 | biostudies-literature
UnknownSPT6 functions in transcriptional pause/release via PAF1C recruitment.
Not available
S-EPMC9714687 | biostudies-literature
UnknownNELF and PAF1C complexes are core transcriptional machineries controlling colon cancer stemness.
Not available
S-EPMC10873196 | biostudies-literature
UnknownStructural basis for evolutionarily conserved interactions between TFIIS and Paf1C.
Not available
S-EPMC11164251 | biostudies-literature
UnknownA CSB-PAF1C axis restores processive transcription elongation after DNA damage repair.
Not available
S-EPMC7910549 | biostudies-literature
UnknownGenic and global functions for Paf1C in chromatin modification and gene expression in Arabidopsis.
Not available
S-EPMC2515192 | biostudies-literature
UnknownMultiple direct and indirect roles of Paf1C in elongation, splicing, and histone post-translational modifications.
Not available
S-EPMC11071476 | biostudies-literature
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