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TranscriptomicsTranscription profiling by array of embryonal carcinoma cell line P19 with or without expressoin of Blimp1-EGFP fusion protein over a 48-hour time-course to study the role of Blimp1 in transcription regulation in pluripotent embryonic cells
Genome-wide expression analysis was performed with the aim of investigating transcriptional changes mediated by the transcription factor B lymphocyte-induced maturation protein-1 (Blimp1) in the context of pluripotent embryonic cells, with the aim of drawing parallels to its functions in mouse primo...
ORGANISM(S): Mus musculus 
2013-05-11 | E-MTAB-865 | biostudies-arrayexpress
TranscriptomicsExpression analysis of Lrig1-eGFP+ve and -ve cells from small intestine
Expression profiling array of Lrig1 expressing and non-expressing cells isolated by flow cytometry from the intestinal epithelium of Lrig1:eGFPiresCreERT2 (Lrig1 KI) animals.
ORGANISM(S): Mus musculus 
2013-08-15 | E-MTAB-1602 | biostudies-arrayexpress
GenomicsTranscriptional binding patterns involved in promoter-enhancer interactions.
This study was designed to be able to determine the interactions between promoter and enhancer elements in the haematopoietic stem/progenitor cell line HPC-7. The next step was to investigate if specific transcription factors could be associated with looping events and to determine if there was co-o...
ORGANISM(S): Mus musculus 
2016-02-29 | E-MTAB-3954 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of Human Umbilical Vein Endothelial Cells (HUVEC) after treatment with Erg or control antisense (GeneBloc)
The endothelial transcription factor Erg (Ets Related Gene) plays an important role in homeostasis and angiogenesis by regulating many endothelial functions including survival and junction stability. Here we show that Erg regulates endothelial cell migration. Transcriptome profiling of Erg-deficient...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-32984 | biostudies-arrayexpress
GenomicsAP2gamma ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor AP2gamma was stably expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1600 | biostudies-arrayexpress
GenomicsBLIMP1 ChIPseq
As a part of a modelling experiment for transcriptional control of mouse primordial germ cell specification, the transcription factor BLIMP1 was transiently expressed in the mouse p19 embryonal carcinoma cell line and its genome wide binding sites were defined using ChIPseq.
ORGANISM(S): Mus musculus 
2013-07-17 | E-MTAB-1599 | biostudies-arrayexpress
TranscriptomicsChromatine immunoprecipitation of mouse thymus and HPC-7 cell line with anti-acetyl histone H3 antibody.
Histone modification ChIP-on-chip assays were performed in hematopoietic cell lines to identify potential cis-regulatory regions
ORGANISM(S): Mus musculus 
2010-06-17 | E-TABM-882 | biostudies-arrayexpress
TranscriptomicsTracking Early Mammalian Organogenesis – Prediction and Validation of Differentiation Trajectories at Whole Organism Scale
This project is based on the extension of the single cell transcriptomics atlas of mouse development towards E9.5. Inference of cell differentiation trajectories was carried out using Waddington-Optimal Transport, and the resulting computational reconstruction was contrasted with grafting experiment...
ORGANISM(S): Mus musculus 
2023-01-01 | E-MTAB-11763 | biostudies-arrayexpress
GenomicsGenome-wide analysis of GATA1, GATA2, RUNX1, FLI1 and SCL binding in primary human megakaryocytes
We have mapped the binding sites for the five key regulators GATA1, GATA2, RUNX1, FLI1 and TAL1/SCL in primary human megakaryocytes. Statistical analysis identified subsets of enriched as well as depleted combinatorial binding patterns. In particular simultaneous binding by all 5 factors was highly ...
ORGANISM(S): Homo sapiens 
2011-06-01 | E-GEOD-24674 | biostudies-arrayexpress
GenomicsCytokine-mediated differentiation reflects genome-wide loss of a uSTAT transcriptional program
uSTAT transcriptional program HPC7 cells were fixed with either 1% formaldehyde for 10 mins. Chromatin was isolated, sonicated for 7 mins (30 sec on, 30 sec off), and specific antibodies were used to pull down the transcription factors of insterest after a pre-clearing step. Chromatin was washed, de...
ORGANISM(S): Mus musculus 
2016-01-05 | E-GEOD-70697 | biostudies-arrayexpress
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