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UnknownDeleting Full Length Titin Versus the Titin M-Band Region Leads to Differential Mechanosignaling and Cardiac Phenotypes.
Not available
S-EPMC6453709 | biostudies-literature
TranscriptomicsThe smooth muscle titin filament system regulates uterus contractility and implantation.
We investigated the impact of smooth-muscle–specific deletion of titin M-band exons 1–2. Understanding how disruption of titin M-band signaling alters uterine smooth-muscle physiology provides insight into the molecular mechanisms controlling coordinated uterine peristalsis, embryo positioning, and ...
ORGANISM(S): Mus musculus 
2026-09-16 | E-MTAB-17587 | biostudies-arrayexpress
UnknownResolving titin's lifecycle and the spatial organization of protein turnover in mouse cardiomyocytes.
Not available
S-EPMC6911189 | biostudies-literature
ProteomicsTitin BioID - protein and peptide pull-down
Proximity proteomics has greatly advanced the analysis of native protein complexes and subcellular structures in culture, but has not been amenable to study development and disease in vivo. Here, we generated a knock-in mouse with the biotin ligase (BioID) inserted at titin’s Z-disc region to identi...
ORGANISM(S): Mus musculus (Mouse) 
2020-05-18 | PXD017341 | Pride
Mouse Titin Biotinylation sites Bioid 
UnknownInterspecies differences in virus uptake versus cardiac function of the coxsackievirus and adenovirus receptor.
Not available
S-EPMC4054445 | biostudies-literature
UnknownReducing RBM20 activity improves diastolic dysfunction and cardiac atrophy.
Not available
S-EPMC5143357 | biostudies-literature
UnknownDeconstructing sarcomeric structure-function relations in titin-BioID knock-in mice.
Not available
S-EPMC7305127 | biostudies-literature
ProteomicsMislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3
Severe forms of dilated cardiomyopathy (DCM) are associated with point mutations in the alternative splicing regulator RBM20 that are frequently located in the arginine/serine-rich domain (RS-domain). Such mutations can cause defective splicing and cytoplasmic mislocalization, which leads to the for...
ORGANISM(S): Homo sapiens (Human) 
2023-06-19 | PXD038790 | Pride
Human Heart Splicing Dilated cardiomyopathy 
UnknownCAR links hypoxia signaling to improved survival after myocardial infarction.
Not available
S-EPMC10073142 | biostudies-literature
UnknownThe cell adhesion protein CAR is a negative regulator of synaptic transmission.
Not available
S-EPMC6494904 | biostudies-literature
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