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ProteomicsXL-MS Analysis of Recombinant GPR158:RGS7:Gb5 Complex in Detergent Micelles
GPR158 is widely expressed in the brain and have been implicated in depression, cognition, mood and several cancers. GPR158 is also involved in retinal photoreceptor signaling along with it involvement in synaptic organization. GPR158 interact with G-protein regulator-RGS7 and brings it to plasma me...
ORGANISM(S): Homo sapiens (Human) 
2023-03-11 | PXD026603 | Pride
Rgs7 Orphan gpcr Gb5 Gpcr-rgs complex Membrane protein complex Gpr158 G-protein coupled receptor Chemical crosslinking 
TranscriptomicsGPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice
Impairment in social communication skills is a hallmark feature of autism spectrum disorder (ASD). The role of G-protein coupled receptor 158 (GPR158) in ASD remains largely unexplored. In this study, we observed both constitutive and cell/tissue-specific knockouts of Gpr158 in pyramidal neurons or ...
ORGANISM(S): Mus musculus 
2024-09-04 | GSE276304 | GEO
GenomicsGPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice
GPR158 in pyramidal neurons mediates social novelty behavior via modulating synaptic transmission in male mice
PRJNA1156588 | ENA
TranscriptomicsGPR158 Activates Cellular Stress Responses in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways: Implications for Ocular Hypertension
Background: the major risk factor for glaucoma is ocular hypertension, a disorder caused by reduced outflow of aqueous humor through the trabecular meshwork. In a previous pharmacogenomic screen for genes associated with ocular hypertension, we identified the novel G protein-coupled receptor, GPR158...
ORGANISM(S): Homo sapiens 
2024-06-30 | GSE236016 | GEO
UnknownOrphan receptor GPR158 controls stress-induced depression.
Not available
S-EPMC5823542 | biostudies-literature
UnknownExpression Mapping and Functional Analysis of Orphan G-Protein-Coupled Receptor GPR158 in the Adult Mouse Brain Using a GPR158 Transgenic Mouse.
Not available
S-EPMC10046084 | biostudies-literature
GenomicsGPR158 Activates Cellular Stress Responses in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways: Implications for Ocular Hypertension
GPR158 Activates Cellular Stress Responses in Trabecular Meshwork Cells of the Eye’s Aqueous Outflow Pathways: Implications for Ocular Hypertension
PRJNA988435 | ENA
UnknownGPR158 in the Visual System: Homeostatic Role in Regulation of Intraocular Pressure.
Not available
S-EPMC6533807 | biostudies-literature
UnknownExpression and functional role of orphan receptor GPR158 in prostate cancer growth and progression.
Not available
S-EPMC4333349 | biostudies-literature
UnknownStructure of the class C orphan GPCR GPR158 in complex with RGS7-Gβ5.
Not available
S-EPMC8611064 | biostudies-literature
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