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ProteomicsGPR56 (ADGRG1) and Transglutaminase (TG2) interaction in Regulation of Mesenchymal Transition in Glioblastoma.
G protein-coupled receptor 56 (GPR56/ADGRG1) is an adhesion GPCR with an essential role in brain development and cancer. Elevated expression of GPR56 was observed in the clinical specimens of Glioblastoma (GBM), a highly invasive primary brain tumor. However, we found the expression to be variable a...
ORGANISM(S): Homo sapiens (Human) 
2022-05-04 | PXD031569 | Pride
Tg2 Gpr56 Adgrg1 Mesenchymal Gbm 
ProteomicsProteomics in HT1080 WT and GPR56 KO cells
G-protein-coupled receptors (GPCRs) mediate most cellular responses to hormones, neurotransmitters as well as environmental stimulants. However, whether GPCRs participate in modulation of tissue homeostasis through ferroptosis remains unclear. By GPCR cDNA library screening, here we identify that GP...
ORGANISM(S): Homo sapiens (Human) 
2024-10-11 | PXD054855 | Pride
Ht1080 gpr56 ko  human fibrosarcoma proteomics 
GenomicsGPR56/ADGRG1 is associated with response to antidepressant treatment
GPR56/ADGRG1 is associated with response to antidepressant treatment
PRJNA610594 | ENA
GenomicsGPR56/ADGRG1 inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma [GIC7]
GPR56/ADGRG1 inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma [GIC7]
PRJNA413406 | ENA
GenomicsADGRG1/GPR56 knockdown in cord blood CD34+ cells
ADGRG1/GPR56 knockdown in cord blood CD34+ cells
PRJNA631400 | ENA
TranscriptomicsRNA-Seq of GPR56+/- populations
Insights into the complex clonal architecture of acute myeloid leukemia (AML) unravelled by deep sequencing technologies have challenged the concept of AML as a hierarchically organised disease initiated and driven by rare self-renewing leukemic stem cells (LSCs). The lack of clone-specific surface ...
ORGANISM(S): Homo sapiens 
2020-05-01 | GSE68623 | GEO
GenomicsGPR56 (ADGRG1) and Transglutaminase (TG2) interaction in Regulation of Mesenchymal Transition in Glioblastoma
GPR56 (ADGRG1) and Transglutaminase (TG2) interaction in Regulation of Mesenchymal Transition in Glioblastoma
PRJNA793581 | ENA
TranscriptomicsGPR56/ADGRG1 inhibits Mesenchymal Differentiation and Radioresistance in Glioblastoma
A mesenchymal transition occurs both during natural evolution of glioblastoma (GBM) and in response to therapy. However, the molecular mechanisms underlying mesenchymal differentiation are not well understood. We have found that the adhesion G protein-coupled receptor, GPR56/ADGRG1, inhibits mesench...
ORGANISM(S): Homo sapiens 
2017-10-01 | GSE94765 | GEO
GenomicsSensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
Sensing steroid hormone 17α-hydroxypregnenolone by GPR56 enables protection from ferroptosis-induced liver injury
PRJNA1148929 | ENA
TranscriptomicsGPR56/ADGRG1 is associated with response to antidepressant treatment
It remains unclear why many patients with depression do not respond to antidepressant treatment. In three cohorts of individuals with depression and treated with serotonin-norepinephrine reuptake inhibitor (N=424) we show that responders, but not non-responders, display an increase of GPR56 mRNA in ...
ORGANISM(S): Homo sapiens 
2020-03-31 | GSE146446 | GEO
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