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TranscriptomicsA protective strategy against hyperinflammatory responses requiring the non-transcriptional actions of GPS2
The association between hyper-inflammatory states and numerous diseases is widely recognized, but our understanding of the molecular strategies that have evolved to prevent uncontrolled activation of inflammatory responses remains incomplete. Here, we report a critical, non-transcriptional role of G...
ORGANISM(S): Homo sapiens 
2012-03-23 | E-GEOD-35197 | biostudies-arrayexpress
ProteomicsInhibition of MUL1-mediated ubiquitination promotes mitochondria-associated translation
G-Protein Pathway Suppressor 2 (GPS2) is an inhibitor of non-proteolytic ubiquitination mediated by the E2 ubiquitin-conjugating enzyme Ubc13. Previous studies have associated GPS2-mediated restriction of K63 ubiquitination with the regulation of insulin signaling, inflammatory responses and mitocho...
ORGANISM(S): Mus musculus (Mouse) 
2025-09-08 | PXD030187 | Pride
Lc-msmubiquitin I.e. human Pabpc Mitochondria stress response (msr)s Plasma Mitochondria Mul1 Gps2 Liver 
GenomicsGPS2 and HDAC3 ChIP-Seq in GPS2-KO MCF-7 [ChIP-Seq]
GPS2 and HDAC3 ChIP-Seq in GPS2-KO MCF-7 [ChIP-Seq]
PRJNA1051646 | ENA
GenomicsGPS2 and HDAC3 RNA-Seq in GPS2-KO MCF-7 [RNA-Seq]
GPS2 and HDAC3 RNA-Seq in GPS2-KO MCF-7 [RNA-Seq]
PRJNA1051984 | ENA
GenomicsTranscriptome comparison between WT and GPS2 liver knockout (LKO) livers and GPS2 NCOR PPARa cistrome and epigenome analysis in livers.
Transcriptome comparison between WT and GPS2 liver knockout (LKO) livers and GPS2 NCOR PPARa cistrome and epigenome analysis in livers.
PRJNA450317 | ENA
GenomicsGPS2 sensitizes IL4 pathway via the recruitments of KDM1A
GPS2 sensitizes IL4 pathway via the recruitments of KDM1A
PRJNA766742 | ENA
UnknownSUMOylation of GPS2 protein regulates its transcription-suppressing function.
Not available
S-EPMC4142620 | biostudies-literature
GenomicsGPS2 and HDAC3 ChIP-Seq in GPS2-KO MCF-7 [ChIP-Seq]
Within the nucleus, G-Protein Pathway Suppressor 2 (GPS2) was first recognized as a component of the core NCoR/SMRT corepressor complex. This is a multi-protein complex that functions as a corepressor for a variety of transcription factors, including nuclear receptors, and promotes the deacetylation...
ORGANISM(S): Homo sapiens 
2025-05-05 | GSE250040 | GEO
TranscriptomicsGPS2 and HDAC3 RNA-Seq in GPS2-KO MCF-7 [RNA-Seq]
Within the nucleus, G-Protein Pathway Suppressor 2 (GPS2) was first recognized as a component of the core NCoR/SMRT corepressor complex. This is a multi-protein complex that functions as a corepressor for a variety of transcription factors, including nuclear receptors, and promotes the deacetylation...
ORGANISM(S): Homo sapiens 
2025-05-05 | GSE250075 | GEO
GenomicsTranscriptome comparison between WT and GPS2 liver knockout (LKO) livers and GPS2 NCOR PPARa cistrome and epigenome analysis in livers.
Obesity-associated lipid overload triggers non-alcoholic fatty liver diseases (NAFLD), which in part may be driven by alterations of regulatory transcription networks and hepatocyte-selective epigenomes. Here we demonstrate that G protein pathway suppressor 2 (GPS2), a subunit of the nuclear recepto...
ORGANISM(S): Mus musculus 
2019-03-12 | GSE113157 | GEO
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