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MetabolomicsZingerone treats postmenopausal osteoporosis via increased ferroptosis sensitivity by p53-mediated regulation of Sat1 and Gpx4 expression

Zingerone, a component of dried ginger, has known anti-ulcer and bone growth-promoting effects, but its impact on postmenopausal osteoporosis (PO) is unclear. This study investigates the therapeutic potential and underlying mechanisms of zingerone in PO. A concentration-dependent effect identifie...

2025-08-07 | MTBLS12829 | MetaboLights
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model.
Glutathione peroxidase (Gpx) is a selenium-containing enzyme that catalyses the reduction of a variety of biological peroxides at the expense of reduced glutathione (GSH). Gpx1 is the most abundant isoform and its role has been implicated in neurodegenerative disorders such as ParkinsonM-bM-^@M-^Ys ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23162 | biostudies-arrayexpress
GenomicsTranscriptional Regulation of the GPX1 Gene by TFAP2C and Aberrant CpG Methylation in Human Breast Cancer
The complexity of gene regulation has created obstacles to defining mechanisms that establish the patterns of gene expression characteristic of the different clinical phenotypes of breast cancer. Transcription factor TFAP2C plays a critical role in the regulation of both estrogen receptor-alpha (ERM...
ORGANISM(S): Homo sapiens 
2012-09-12 | E-GEOD-36351 | biostudies-arrayexpress
ProteomicsGPX1 expression promotes stemness and aggressiveness in sarcomas
The sarcomagenic process initiates upon the tumoral transformation of mesenchymal stromal/stem cell (MSCs) or MSC-derived cell types. Experimental evidence also supports that sarcoma evolution is in part driven by the emergence of subpopulations of cancer stem cells (CSCs) after the accumulation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD053403 | Pride
Myxoid liposarcoma Proteomics Gpx1 Cancer stem cells Sarcoma Oxidative stress 
Proteomicsglutathione peroxidase 1 (GPX1) interactome
Native protein extracts from 2-week-old seedlings of wild-type and GPX1-OE lines were used to identify interactions partners of glutathione peroxidase 1 in rice.
ORGANISM(S): Oryza Sativa 
2022-07-07 | PXD027157 | JPOST Repository
ProteomicsProteomic charaterization of GPX1 depletion in sarcoma models
The sarcomagenic process initiates upon the tumoral transformation of mesenchymal stromal/stem cell (MSCs) or MSC-derived cell types. Experimental evidence also supports that sarcoma evolution is in part driven by the emergence of subpopulations of cancer stem cells (CSCs) after the accumulation of ...
ORGANISM(S): Homo sapiens (Human) 
2025-10-20 | PXD052595 | Pride
Human Sarcoma Cscs Gpx1 
GenomicsInhibition of TNBC metastasis by Gpx1
Inhibition of TNBC metastasis by Gpx1
PRJNA522914 | ENA
TranscriptomicsGlobal transcriptomic profiling of ischemic/reperfusion injury in an in vivo mouse model.
This SuperSeries is composed of the following subset Series: GSE23160: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo wild-type mouse model. GSE23162: Global transcriptomic profiling of ischemic/reperfusion injury in an in vivo Gpx1 -/- transgenic mouse model. Refer to ...
ORGANISM(S): Mus musculus 
2011-01-10 | E-GEOD-23163 | biostudies-arrayexpress
GenomicsRNA-Sequencing for pancreatic cancer cells with scramble-shRNA and GPx1-shRNA
RNA-Sequencing for pancreatic cancer cells with scramble-shRNA and GPx1-shRNA
PRJNA414239 | ENA
TranscriptomicsInhibition of TNBC metastasis by Gpx1
Gpx1 plays a vital role in the metastasis of TNBC cells by regulating cell adhesion. Depletion of Gpx1 reduces the survival, migration, and invasion of TNBC cells in vitro. Transcriptomic and signaling pathway analyses demonstrate that depletion of Gpx1 essentially impairs cell adhesion/spreading by...
ORGANISM(S): Homo sapiens 
2019-11-30 | GSE126675 | GEO
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