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Small molecules not only represent cellular building blocks and metabolic intermediates, but also regulatory ligands and signaling molecules that interact with proteins. Although these interactions affect cellular metabolism, growth, and development, they have been largely understudied. Herein, we d...
2018-07-19 | MTBLS94 | MetaboLights
Osteoarthritis (OA) is a prevalent and debilitating disease that predominantly affects load-bearing joints (1). Knee osteoarthritis (KOA) is characterized by the progressive degradation of nearly all structures within the knee joint, leading to pain, stiffness, and reduced joint mobility (2-4). The ...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-27 | PXD064341 | Pride
Animals and samplings: Research involving animal experimentation has been approved by the author's institution (authorization number 35-14) and conforms to NIH guidelines. All-male and all-female rainbow trout populations were obtained from the INRA experimental fish farm (Drennec, France) using bre...
ORGANISM(S): Oncorhynchus mykiss 
A genome-wide CRISPR-Cas9 knockout screen was performed in the breast cancer cell lines T47D, MCF7, and CAMA-1 to identify genes modulating sensitivity and resistance to capivasertib, a selective AKT inhibitor. Cells were transduced with a CRISPR library, followed by treatment with capivasertib or v...
ORGANISM(S): Homo sapiens 
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