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ProteomicsCellular interactome of HSV-1 pUL21
The herpes simplex virus (HSV)-1 protein pUL21 is essential for efficient virus replication and dissemination. While pUL21 has been shown to promote multiple steps of virus assembly and spread, the molecular basis of its function remained unclear. Here we identify that pUL21 is a virus-encoded adapt...
ORGANISM(S): Homo sapiens (Human) 
2021-08-05 | PXD027257 | Pride
Col4a3bp Herpes simplex virus 1 Herpesvirus Protein phosphatase 1 Cert Silac Pp1 
ProteomicsTarget engagement of Tau antibodies induces reversal of proteomic dyshomeostasis in a mouse model of tauopathy
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD045799 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
ProteomicsProteostasis as a fundamental principle of Tau immunotherapy – study in male mice
The microtubule-associated protein Tau is a driver of neuronal dysfunction in Alzheimer’s disease and numerous other tauopathies. In this process, Tau initially undergoes subtle changes to its abundance, subcellular localization and a vast array of post-translational modifications, including phospho...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051830 | Pride
Mouse Alzheimer’s disease Antibody Proteomics Tau Phosphoproteomics Tauopathies 
TranscriptomicsSequencing of HSV-1 genomic DNA to identify genomic variation resulting from selective pressure imposed by mutation of the PP1 binding site in the pUL21 gene
The pUL21 gene is essential for efficient replication and dissemination in herpes simplex virus 1 (HSV-1) but the molecular basis for its function is not well understood. Experimental work revealed that pUL21 is a virus-encoded adaptor of protein phosphatase 1 (PP1). Mutation of the specific motif i...
ORGANISM(S): Human alphaherpesvirus 1 
2021-07-31 | E-MTAB-10788 | biostudies-arrayexpress
UnknownMultimodal chiropractic care for migraine: A pilot randomized controlled trial.
Not available
S-EPMC9670157 | biostudies-literature
UnknownHerpes simplex virus 1 protein pUL21 alters ceramide metabolism by activating the interorganelle transport protein CERT.
Not available
S-EPMC9668737 | biostudies-literature
ProteomicsWhole-cell and plasma membrane proteomics of herpes simplex virus-1 infection reveals cell surface remodelling via pUL56-mediated GOPC degradation
Herpesviruses are ubiquitous in the human population and they extensively remodel the cellular environment during infection. Multiplexed quantitative proteomic analysis over the time-course of herpes simplex virus (HSV)-1 infection was used to characterize changes in the host-cell proteome and the k...
ORGANISM(S): Homo sapiens (Human) Human alphaherpesvirus 1 
2020-10-15 | PXD021351 | Pride
Quantitative proteomics Uncharacterized orf Immune evasion Membrane trafficking Virus host interaction Proteasomal degradation Herpesvirus 
UnknownTemporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.
Not available
S-EPMC7539533 | biostudies-literature
UnknownPatient-reported outcomes before treatment for localized prostate cancer: are there differences among countries? Data from the True North Global Registry.
Not available
S-EPMC10623840 | biostudies-literature
UnknownClinical characteristics of children and young people admitted to hospital with covid-19 in United Kingdom: prospective multicentre observational cohort study.
Not available
S-EPMC7488201 | biostudies-literature
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