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ProteomicsWDR4 conditional knockout in mouse cerebellar granule progenitors for proteome analysis
To uncover candidates which are WDR4 downstream effectors regulating cerebellar granule neuron proliferation phenotype, we utilized quantitative proteomics analysis (TMT labeling) with granule neuron progenitors from P7 wdr4 conditional knockout (using Atoh1-Cre) and control cerebella.
ORGANISM(S): Mus musculus (Mouse) 
2023-03-11 | PXD022319 | Pride
Granule progenitors Mouse Tmt Wdr4 Cerebellum 
GenomicsNotch signaling between cerebellar granule cell progenitors
Notch signaling between cerebellar granule cell progenitors
PRJNA642138 | ENA
GenomicsSingle-cell whole-genome sequencing of primary mouse cerebellar granule neuron progenitors
Single-cell whole-genome sequencing of primary mouse cerebellar granule neuron progenitors
PRJEB54869 | ENA
TranscriptomicsMyc and N-myc induce distinct medulloblastoma subgroups via Miz1
Medulloblastomas (MBs) are cerebellar tumors that can be classified into molecularly distinct subgroups that differ in pathology and prognosis. The mechanisms that underlie subgroup specification are largely unknown. While human SHH MBs express MYCN, Group3 (G3) MBs are associated with c-MYC (MYC) o...
ORGANISM(S): Mus musculus 
2016-01-21 | E-GEOD-66093 | biostudies-arrayexpress
TranscriptomicsNotch signaling between cerebellar granule cell progenitors
During cerebellar development, maternal granule cell progenitors (GCPs) divide to produce not only postmitotic granule cells (GCs) but also sister GCPs. However, molecular machinery to proportionally produce distinct sister cell types from seemingly uniform GCPs is still elusive. Here we report Notc...
ORGANISM(S): Mus musculus 
2020-06-27 | GSE153313 | GEO
TranscriptomicsCerebellar Granule Neuron Temporal-NFI Microarray Data
Dendrite and synapse development are critical for establishing appropriate neuronal circuits, and disrupted timing of these events can alter connectivity leading to disordered neural function. In early postnatal development of cerebellar granule neurons (CGNs), the expression of many genes is tempor...
ORGANISM(S): Mus musculus 
2012-11-07 | E-GEOD-42018 | biostudies-arrayexpress
UnknownCerebellar granule cell replenishment postinjury by adaptive reprogramming of Nestin+ progenitors.
Not available
S-EPMC5614835 | biostudies-literature
TranscriptomicsTranscription profiling of mouse with Hedgehog-induced medulloblastoma reveals oncogenic Hedgehog signaling promotes medulloblastoma from lineage-restricted granule cell progenitors
Origins of the brain tumor, medulloblastoma, from stem cells or restricted pro-genitor cells are unclear. To investigate this, we activated oncogenic Hedgehog signaling in multipotent and lineage-restricted CNS progenitors. We observed that normal unipo-tent cerebellar granule neuron precursors (CGN...
ORGANISM(S): Mus musculus 
2008-10-21 | E-GEOD-11859 | biostudies-arrayexpress
GenomicsGermline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma [bulkRNA]
Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma [bulkRNA]
PRJNA1082362 | ENA
UnknownNotch Signaling between Cerebellar Granule Cell Progenitors.
Not available
S-EPMC8121261 | biostudies-literature
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