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ProteomicsGranzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis in cancer cells
Cytotoxic lymphocyte protease granzyme M (GrM) is a potent inducer of tumor cell death in vitro and in vivo. The apoptotic phenotype and mechanism by which it induces cell death however, remain poorly understood and controversial. Here, we show that GrM-induced cell death was largely caspase-depende...
ORGANISM(S): Homo sapiens (Human) 
2013-11-27 | PXD000252 | Pride
Human Lc-msms Granzyme m 
ProteomicsGrM - Human and mouse granzyme M display divergent and species-specific substrate specificities
Complementary positional proteomics of human and mouse granzyme M treated K-562 lysates
2012-05-23 | PRD000347 | Pride
ProteomicsGranzyme B cleaves Tenascin-C to release its C-terminal FBG-like domain into the synovial fluid of patients with rheumatoid arthritis
Raw files and search engine files for the proteomics data resulting from the digestion of Tenascin-C by Granzyme B
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-02-20 | MSV000094138 | MassIVE
UnknownGranzyme M: behind enemy lines.
Not available
S-EPMC3921602 | biostudies-literature
ProteomicsHuman Differentiated SH-SY5Y neuroblastoma cells treated with Granzyme K
Human Differentiated SH-SY5Y neuroblastoma cells treated with 150 nM GrK alone or together with 100 nM SCH79797 PAR-1 inhibitor to evaluate the impact of granzyme K (GrK) on neuronal functions.
ORGANISM(S): Homo sapiens (Human) 
2025-06-24 | PXD064640 | Pride
Neuroblastoma Alzheimer's disease Granzyme k Sh-sy5y 
UnknownGranzyme M expressed by tumor cells promotes chemoresistance and EMT in vitro and metastasis in vivo associated with STAT3 activation.
Not available
S-EPMC4467404 | biostudies-literature
UnknownNK cell intrinsic regulation of MIP-1α by granzyme M.
Not available
S-EPMC3973215 | biostudies-literature
TranscriptomicsMicroRNAs regulate DC maturation via M-CSFR
We identify a panel of microRNAs that are differentially expressed during both spontaneous and LPS-induced DC maturation and show the M-CSF receptor (M-CSFR) as a key target for microRNA-mediated regulation. MicroRNA-22, -34a and -155 are up-regulated in mature GM-CSF-generated DC and mediate M-CSFR...
ORGANISM(S): Mus musculus 
2013-11-04 | E-MEXP-3311 | biostudies-arrayexpress
TranscriptomicsHuman Monocytes to M-CSF differentiated Macrophages
This dataset was created to study M-CSF dependent in vitro differentiation of human monocytes to macrophages as a model process to demonstrate that independent component analysis (ICA) is a useful tool to support and extend knowledge-based strategies and to identify complex regulatory networks or no...
ORGANISM(S): Homo sapiens 
2011-11-07 | E-GEOD-9801 | biostudies-arrayexpress
UnknownGranzyme M targets topoisomerase II alpha to trigger cell cycle arrest and caspase-dependent apoptosis.
Not available
S-EPMC3921589 | biostudies-literature
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