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ProteomicsDiscovery proteomics studies for the identification of a protein panel associated with the response to pemetrexed in platinum drug resistant cancer
Pemetrexed is a drug largely used in lung cancer, mesothelioma and proposed in some cases of ovarian cancers, a particularly severe cancer type. In this latest tumor type, therapy relies on debulking surgery and platinum-based chemotherapy. Despite the initial high response rates to platinum drugs, ...
ORGANISM(S): Homo sapiens (Human) 
2018-06-06 | PXD007056 | Pride
Platinum drug resistance Lc ms/ms Ovarian cancer Discovery proteomics 
UnknownComplex segmental duplications mediate a recurrent dup(X)(p11.22-p11.23) associated with mental retardation, speech delay, and EEG anomalies in males and females.
Not available
S-EPMC2771536 | biostudies-literature
ProteomicsSUMO-2 activity is inhibited by non-covalent interactions with the Aβ peptide: an exploration of potential pathogenic mechanisms in Alzheimer’s Disease
SUMOylation is a post-translational modification involving the addition of SUMO isoforms to target proteins and plays a role in various biological processes, including neurodegenerative diseases and ocular pathologies. This study investigates the interaction between SUMO-2 and amyloid (Aβ) peptides,...
ORGANISM(S): Homo sapiens (Human) 
2025-08-25 | PXD066055 | Pride
Aβ Protein protein interactions Crosslinking ms Alzheimer’s disease Xl-ms Sumo-2 Cross-linking mass spectrometry 
ProteomicsMitochondrial energetic failure underlies FLVCR1-related sensory neuropathy
Genetic pain loss disorders represent a heterogeneous group of rare diseases mainly characterized by defective nociception. Understanding the underlying molecular mechanism is fundamental to improve the treatment of patients affected by these rare disorders. Feline Leukemia Virus Subgroup C Receptor...
ORGANISM(S): Homo sapiens (Human) 
2026-02-02 | PXD071580 | Pride
Posterior column ataxia and retinitis pigmentosa  pcarp  retinitis pigmentosa  hereditary sensory and autonomic neuropathy  hsan  heme  choline  mams  mercs 
ProteomicsA novel mobile genomic island: introducing ‘cephalosporinase morons’ in Enterobacteriaceae
The exchange of mobile genomic islands (MGIs) between microorganisms is often mediated by phages. As a consequence, not only phage genes are transferred, but also genes that have no particular function in the phage's lysogenic cycle. If they provide benefits to the phage's host, such genes are refer...
ORGANISM(S): Enterobacter cloacae 
2018-08-21 | PXD007113 | Pride
"cephalosporin resistance " Enterobacteriaceae "mobile genomic islands " 
ProteomicsProteomic study identified several proteins involved in cellular processes in recurrent otitis media
Recurrent otitis (ROM) is a pathological conditions in which a children have at least three episodes of acute otitis media over a course of 6 months. In this study we focused in proteins dysregulated between ROM and adenotonsillar hypertrophy (ATH). Tissue sample of seven ROM and seven ATH were obta...
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD022477 | Pride
2-de Recurrent otitis adenotonsillar hypertrophy Lc-ms/ms 
ProteomicsProfiling of the proteome of peripheral blood mononuclear cells of subjects diagnosed with primary open angle glaucoma
This study reports the first characterization of the intracellular proteome of peripheral blood mononuclear cells (PBMC) isolated from subjects diagnosed with primary open angle glaucoma (POAG)by shot-gun proteomics. Glaucoma is a chronic optic neuropathy and among the first causes of irreversible...
ORGANISM(S): Homo sapiens (Human) 
2025-09-22 | PXD059976 | Pride
Glaucoma Peripheral blood mononuclear cells Shot gun proteomics Immune system 
UnknownIdentification of 22 susceptibility loci associated with testicular germ cell tumors.
Not available
S-EPMC8302763 | biostudies-literature
UnknownTreatment adaptations and outcomes of patients experiencing inflammatory bowel disease flares during the early COVID-19 pandemic: the PREPARE-IBD multicentre cohort study.
Not available
S-EPMC9874879 | biostudies-literature
UnknownAssessment, endoscopy, and treatment in patients with acute severe ulcerative colitis during the COVID-19 pandemic (PROTECT-ASUC): a multicentre, observational, case-control study.
Not available
S-EPMC7906670 | biostudies-literature
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