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MetabolomicsDe Novo Pyrimidine Synthesis Is a Collateral Metabolic Vulnerability in NF2-deficient Mesothelioma

Pleural mesothelioma (PM) is one of the deadliest cancers, with limited therapeutic options due to its therapeutically intractable genome, which is characterized by the functional inactivation of tumor suppressor genes (TSGs) and high tumor heterogeneity, including diverse metabolic adaptations. ...

2025-07-07 | MTBLS12461 | MetaboLights
MetabolomicsQuantitative targeted measurements of sphingolipids in Th17 cells before and after the triple knockdown of SPTLC1,2,3 genes (SPT, de novo pathway: sphingolipid metabolism) (part-III)
Not available
ORGANISM(S): Homo sapiens 
ST001677 | MetabolomicsWorkbench
ProteomicsNative protein mapping and visualization of protein interactions in human plasma high-density lipoprotein by 2-DE and LC-MS/MS
A human plasma sample was subjected to non-denaturing micro 2-DE and a gel area (5 mm X 18 mm) which includes high-density lipoprotein (HDL) was cut into 1 mm X 1 mm squares, then the proteins in the 90 gel pieces were analyzed by in-gel trypsin digestion and nano-LC-MS/MS. Grid-cutting of the gel ...
ORGANISM(S): Homo sapiens (Human) 
2014-04-07 | PXD000852 | Pride
High-density lipoproteins Non-denaturing 2-de Nano-lc-ms/ms Lc-mse Plasma Human Hdl 
ProteomicsProteomic study identified several proteins involved in cellular processes in recurrent otitis media
Recurrent otitis (ROM) is a pathological conditions in which a children have at least three episodes of acute otitis media over a course of 6 months. In this study we focused in proteins dysregulated between ROM and adenotonsillar hypertrophy (ATH). Tissue sample of seven ROM and seven ATH were obta...
ORGANISM(S): Homo sapiens (Human) 
2020-12-10 | PXD022477 | Pride
2-de Recurrent otitis adenotonsillar hypertrophy Lc-ms/ms 
ProteomicsAmpulla of Poecilimon amplicata 2-DE spots 9,10,11
The spermatophore was removed and separated into ampulla and spermatophylax. Each of these compartments was solubilized in 6M urea, 3 M thiourea, 70 mM DTT and centrifuged. The supernatant was separated by 2-DE and spots 9,10, and 11 were analyzed by LC-FTICR MS. Spots 9,10, and 11 were occuring on ...
ORGANISM(S): Poecilimon Ampliatus 
2017-09-23 | PXD005030 | JPOST Repository
ProteomicsBPA Gestational Exposure Affects F1 Capacitated Spermatozoa
Proteomic investigations of spermatozoa provide practical tools for distinguishing normal, functional spermatozoa from abnormal spermatozoa. Indeed, two-dimensional gel electrophoresis (2-DE) coupled with mass spectrometry (MS) applies high-throughput industrial applications to identify sperm-specif...
ORGANISM(S): Mus musculus (Mouse) 
2018-01-02 | PXD006829 | Pride
Mouse Spermatozoa 2-de Esi-ms/ms 
TranscriptomicsIdentification of novel tissue-specific transcription arising from E-cadherin/CDH1 intron2: a novel protein isoform increases gastric cancer cell invasion and angiogenesis.
E-cadherin, a protein encoded by the CDH1 gene is the dominant epithelial cell adhesion molecule playing a crucial role in epithelial tissue polarity and structural integrity. The progression of 90% or more carcinomas is believed to be mediated by disruption of normal E-cadherin expression, subcellu...
ORGANISM(S): Homo sapiens 
2012-08-01 | E-GEOD-32540 | biostudies-arrayexpress
GenomicsOrosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
Orosomucoid 2 maintains hepatic lipid homeostasis through suppression of de novo lipogenesis
PRJNA771863 | ENA
GenomicsPotent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants
Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants
PRJNA1442782 | ENA
GenomicsDeterminants of de novo B cell responses to drifted epitopes in post-vaccination SARS-CoV-2 infections data
Determinants of de novo B cell responses to drifted epitopes in post-vaccination SARS-CoV-2 infections data
PRJNA1014484 | ENA
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