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UnknownVascular characterization of mice with endothelial expression of cytochrome P450 4F2.
Not available
S-EPMC4062824 | biostudies-literature
ProteomicsCharacterization of proteome changes after 48 hours of TR-57 (ClpP agonist) treatment
ONC201 is a first-in-class, FDA approved small molecule activator of the mitochondrial ATP-dependent caseinolytic peptidase P (ClpP). This and other related small molecules referred to as ClpP agonists, exert antiproliferative effects in several cancer cell types. We report that ONC201 and highly p...
ORGANISM(S): Homo sapiens (Human) 
2026-09-21 | PXD067842 | Pride
Cell cycle arrest Mitochondrial metabolism Regulation of cell death Clpp agonist Dna damage Triple-negative breast cancer Senescence 
ProteomicsDetermining MELK inhibitor specificity using MIB/MS
The key objectives of this study were to evaluate the selectivity profiles of three MELK inhibitors, 8a, HTH, and OTS, using a cell-based assay, in order to identify a highly selective inhibitor to subsequently investigate MELK function. To this end, we utilized a chemical proteomics approach called...
ORGANISM(S): Homo sapiens (Human) 
2020-01-09 | PXD016022 | Pride
Chemoproteomics Lfq Kinase enrichment 
ProteomicsProteomics and phosphoproteomics analysis of SUM159 cells upon ClpP activation with ONC201 and TR57 compounds
ClpP activators ONC201 and related small molecules (TR compounds, Madera Therapeutics), have demonstrated significant anti-cancer potential in an array of in vitro and in vivo studies, including clinical trials for refractory solid tumors. Though progress has been made in identifying specific phenot...
ORGANISM(S): Homo sapiens (Human) 
2023-05-10 | PXD038990 | Pride
Drug development Drug mechanism Cancer Clpp 
UnknownSingle-cell RNA sequencing of peripheral blood links cell-type-specific regulation of splicing to autoimmune and inflammatory diseases.
Not available
S-EPMC11631754 | biostudies-literature
UnknownGenetic determinants for cadmium and arsenic resistance among Listeria monocytogenes serotype 4b isolates from sporadic human listeriosis patients.
Not available
S-EPMC3623226 | biostudies-literature
ProteomicsMablango_ClpP_HYTANE_P124_Lumos
This dataset consists of 6 raw MS files, acquired on Thermo Fusion Lumos mass spectrometer operated in Data Dependent Acquisition mode. Samples were generated by Keith Wong. Sample processing and mass spectrometry acquisition was performed by Cassandra Wong. Data analysis was performed by Cassandra...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2022-06-13 | MSV000089642 | MassIVE
UnknownGlobal multi-ancestry genome-wide analyses identify genes and biological pathways associated with thyroid cancer and benign thyroid diseases.
Not available
S-EPMC12900643 | biostudies-literature
UnknownThe National COVID Cohort Collaborative (N3C): Rationale, design, infrastructure, and deployment.
Not available
S-EPMC7454687 | biostudies-literature
UnknownRacial and Ethnic and Rural Variations in the Use of Hybrid Prenatal Care in the US.
Not available
S-EPMC11624583 | biostudies-literature
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