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GenomicsClonal evolution in myeloma: the impact of maintenance lenalidomide and depth of response on the genetics and sub-clonal structure of relapsed disease in uniformly treated newly diagnosed patients
The emergence of treatment resistant sub-clones is a key feature of relapse in multiple myeloma. Therapeutic attempts to extend remission and prevent relapse include the maximisation of response and use of maintenance therapy. We used whole exome sequencing to study the genetics of paired presentati...
EGAS00001003539 | EGA
GenomicsUAMS - Myeloma Institute Data Access Committee
Data Access Committee EGAC00001000845
EGAC00001000845 | EGA
Genomicsena-DATASET-UAMS-17-03-2019-03:57:35:391-32 - samples
Series of 56 paired presentation, relapse and control samples from newly diagnosed, uniformly treated myeloma patients. Deep of treatment response and maintenance allocation (active observation or lenaldiomide) was determined for all. All samples underwent whole exome sequencing with additional bait...
EGAD00001004846 | EGA
TranscriptomicsGenetic variegation of clonal architecture and stem cells in leukaemia
Little is known of the genetic architecture of cancer at the subclonal and single cell level or in the stem-like cells responsible for cancer clone maintenance and propagation. We have examined this issue in ALL in which ETV6-RUNX1 gene fuson is an early or initiating genetic lesion followed by a mo...
ORGANISM(S): Homo sapiens 
2010-12-16 | E-GEOD-24412 | biostudies-arrayexpress
TranscriptomicsDistinctive genotypes in infants with T-cell acute lymphoblastic leukaemia
Infant T-cell Acute Lymphoblastic Leukaemia (iT-ALL) is a very rare and poorly defined entity with a poor prognosis. We assembled a unique series of thirteen cases of infants with T-ALL which allowed us to identify genotypic abnormalities and to investigate prenatal origins. Matched samples (diagn...
ORGANISM(S): Homo sapiens 
2015-07-30 | E-GEOD-67271 | biostudies-arrayexpress
Genomicsena-DATASET-SC-16-09-2014-14:22:12:125-153 - samples
Description not provided
EGAD00001001014 | EGA
Genomicsena-DATASET-SC-16-09-2014-14:25:48:324-154 - samples
Description not provided
EGAD00001001015 | EGA
GenomicsOrigins and functional consequence of somatic mitochondrial DNA mutations
Recent sequencing studies have extensively explored the somatic alterations present in the nuclear genomes of cancers. Although mitochondria control energy metabolism and apoptosis, the origins and impact of cancer-associated mutations in mitochondrial DNA (mtDNA) are unclear. Here, we analysed soma...
EGAS00001000968 | EGA
TranscriptomicsA human ESC model for MLL-AF4 reveals an impaired early human hemato-endothelial specification
The MLL-AF4 fusion gene is a hallmark genomic aberration in high-risk acute lymphoblastic leukemia in infants. Although it is well-established that MLL-AF4 arises pre-natally during human development, its effects on hematopoietic development in utero remains unexplored. We have created a human-spec...
ORGANISM(S): Homo sapiens 
2011-06-09 | E-GEOD-29869 | biostudies-arrayexpress
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