Laser-captured motor neurons (LCM-MN) from spinal cord sections of AR100 SBMA mice and AR20 wild-type controls were isolated at presymptomatic (3 months), symptomatic (12 months), and late-stage (18 months) time points. RNA-seq profiling was performed using Illumina HiSeq paired-end sequencing to in...
Characterise the molecular pathogenesis of androgen receptor spinal and bulbar muscular atrop (SBMA) causing repeat expansion mutations in human motor neurons generated from patient-specific spinal cord motor neurons from induced pluripotent stem cells and performed time-resolved analysis of transcr...
A comparison of Ostes homozygous mutant soleus muscles to wildtype soleus muscles. Hybridisation of 3 Mouse CNG 25k oligo arrays, using 3 pools of 10 mice(5 male and 5 female) for mutant and WT.
We investigated the gene and exon espression profiling in muscle biopsies of patients affected by inclusion body myosistis, polymyositis and in normal muscle controls
The striking PNS regenerative response to injury rests on the plasticity of adult Schwann cells and their ability to transit between differentiation states, a highly unusual feature in mammals. Using mice with inactivation of Schwann cell c-Jun, we show that the injury response involves c-Jun depen...
