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TranscriptomicsDecorin and EphA2 mediate Carcinoembryonic Antigen Cell Adhesion Molecule 1-L inhibition of colorectal cancer metastasis
Objective We have previously shown that expression of the CEACAM1 long isoform (CC1-L) in metastatic colorectal cancer (CRC) cells results in significant inhibition of liver metastasis via Chemokine (C-C motif) Ligand 2 (CCL2) and Signal Transducer and Activator of Transcription 3 (STAT3) signaling...
ORGANISM(S): Mus musculus 
2015-09-19 | E-GEOD-73208 | biostudies-arrayexpress
UnknownIntravesical rAd-IFNα/Syn3 for Patients With High-Grade, Bacillus Calmette-Guerin-Refractory or Relapsed Non-Muscle-Invasive Bladder Cancer: A Phase II Randomized Study.
Not available
S-EPMC5648171 | biostudies-literature
TranscriptomicsIGF-1 degradation by mast cell chymase promotes delayed cell death in post-ischemic hearts
Coronary heart disease is the leading cause of death worldwide. After an acute myocardial infarction, early reperfusion reduces infarct size, which correlates with improved clinical outcomes. Paradoxically, reperfusion although relieving ischemia, accelerates apoptosis in injured cardiomyocytes, whi...
ORGANISM(S): Mus musculus 
2015-09-01 | E-GEOD-61592 | biostudies-arrayexpress
UnknownSafety and survival with GVAX pancreas prime and Listeria Monocytogenes-expressing mesothelin (CRS-207) boost vaccines for metastatic pancreatic cancer.
Not available
S-EPMC4397277 | biostudies-literature
UnknownA Prospective, Multicenter Study to Assess the Safety and Efficacy of Translingual Neurostimulation Plus Physical Therapy for the Treatment of a Chronic Balance Deficit Due to Mild-to-Moderate Traumatic Brain Injury.
Not available
S-EPMC9291157 | biostudies-literature
ProteomicsIntegrated multiomic analysis of cholangiocarcinoma defines novel molecular subtypes associated with clinical outcome and identifies TNK1 as a therapeutic target
Despite remarkable advances in cancer genomics and targeted therapy, cholangiocarcinoma (CCA) is still one of the deadliest cancers. Current translational approaches have focused on genomic alterations, while leaving proteomic alterations, that may more directly pinpoint therapeutic targets, unexplo...
ORGANISM(S): Homo sapiens (Human) 
2026-06-29 | PXD059245 | Pride
Multiomics Dimensional reduction Hierarchical all-against-all Phosphoproteomics Cholangiocarcinoma Lc-ms/ms 
UnknownAmerican Society of Clinical Oncology Statement: A Conceptual Framework to Assess the Value of Cancer Treatment Options.
Not available
S-EPMC5015427 | biostudies-literature
TranscriptomicsRegulatory complexity revealed by integrated cytological and RNA-seq analyses of meiotic substages in mouse spermatocytes
The juvenile onset of spermatogenesis in mice is analyzed by combining cytological and transcriptomic data in a novel computational analysis, resulting in meiotic substage-specific transcriptomes and the discovery of a transcription factor network that regulates the substages of meiosis. Germ cells ...
ORGANISM(S): Mus musculus 
2016-08-24 | E-GEOD-72833 | biostudies-arrayexpress
TranscriptomicsDevelopmental timecourse of mouse ocular lens and whole embryo control
Identification of genes involved in ocular birth defects remains a challenge. To facilitate the identification of genes associated with cataract, we developed iSyTE (integrated Systems Tool for Eye gene discovery; http://bioinformatics.udel.edu/Research/iSyTE). iSyTE contains microarray gene express...
ORGANISM(S): Mus musculus 
2012-02-16 | E-GEOD-32334 | biostudies-arrayexpress
GenomicsGemone-wide maps of PRC2 complex components and chromatin states in prostate cancer cell lines
We report the high-throughput profiling of PRC2 core subunits chromatin states and histone modifications in two prostate cancer cell lines, androgen-dependent cells LNCaP and androgen-independent cells LNCaP-abl (abl). By obtaining over 1 billion bases of sequence from chromatin immunoprecipitated D...
ORGANISM(S): Homo sapiens 
2012-11-30 | E-GEOD-39459 | biostudies-arrayexpress
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