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TranscriptomicsComparative transcriptome profiling of Amyloid Precursor Protein APP family members in the adult cortex
The β-amyloid precursor protein APP and the related APLPs, undergo complex proteolytic processing giving rise to several fragments. Whereas it is well established that Aβ accumulation is a central trigger for Alzheimer disease (AD), the physiological role of APP family members and their diverse pr...
ORGANISM(S): Mus musculus 
2011-03-18 | E-GEOD-25926 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human chromic myeloid leukemia (CML) patients treated second-line with imatinib after failure of an interferon-alpha based therapy to identify genes with predictive value for primary cytogenetic outcome to imatinib
Identification of genes in CML patients with predictive value for their primary cytogenetic outcome to imatinib. All samples analyzed were taken just before the start of imatinib treatment. Leukemic patients were treated second-line with imatinib after failure of an interferon-alpha based therapy (f...
ORGANISM(S): Homo sapiens 
2006-05-31 | E-MEXP-433 | biostudies-arrayexpress
TranscriptomicsAIM2-responsive genes in colorectal tumor cells
Absent in Melanoma 2 (AIM2) is a member of the HIN-200 family of hematopoietic, IFN-inducible nuclear proteins associated with infection defense and tumor pathology. Recently, AIM2 was found to act as a DNA sensor in innate immunity. In addition, a high frequency of AIM2-alterations was observed in ...
ORGANISM(S): Homo sapiens 
2012-12-13 | E-GEOD-24155 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of D34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes
Profiling CD34+ BCR-ABL+ cells of CML patients in chronic phase or blast crisis to identify differentially expressed stage-specific genes.
ORGANISM(S): Homo sapiens 
2006-08-08 | E-MEXP-480 | biostudies-arrayexpress
TranscriptomicsComparative transcriptome analysis of APPs?-DM and APLP2-KO brains
Despite its key role in Alzheimer pathogenesis, the physiological function(s) of the amyloid precursor protein (APP) and of its proteolytic fragments are still poorly understood. The secreted APPs? ectodomain has been shown to be involved in neuroprotection and synaptic plasticity. The ?-secretase g...
ORGANISM(S): Mus musculus 
2011-05-10 | E-GEOD-27888 | biostudies-arrayexpress
TranscriptomicsMicroRNA profiling of rats with ochratoxin A nephrotoxicity
The objective of this study is to analyze miRNA profiling in the kidneys of rats gavaged with OTA. To profile miRNAs in the kidneys of rats with OTA nephrotoxicity, high-throughput sequencing and bioinformatics approaches were applied to analyze the miRNAs in the kidney of rats following OTA treatme...
ORGANISM(S): Rattus norvegicus 
2014-06-01 | E-MTAB-2475 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human intestinal epithilium in patients suffering from inflammatory bowel disease.
Identification of significant regulated genes in the intestinal epithelium (ileum and colon)
in patients suffering from inflammatory bowel disease (normal vs. activ and non-activ
Crohn's disease and Ulcerative Colitis). This experiment is an extension of experiment E-MEXP-1225. We added 12 n...
ORGANISM(S): Homo sapiens 
2010-01-01 | E-MEXP-2083 | biostudies-arrayexpress
TranscriptomicsExpression data from Shox2 knockout and wildtype right atria of E11.5 mouse hearts
The heartM-bM-^@M-^Ys rhythm is initiated and regulated by a group of specialized cells in the sinoatrial node (SAN), the primary pacemaker of the heart. Abnormalities in the development of the SAN can result in irregular heart rates (arrhythmias). Although several of the critical genes important fo...
ORGANISM(S): Mus musculus 
2013-06-03 | E-GEOD-39924 | biostudies-arrayexpress
TranscriptomicsThe Forkhead factor FoxQ1 influences epithelial differentiation
The Forkhead family of transcription factors comprises numerous members and is implicated in various cellular functions, including cell growth, apoptosis, migration and differentiation.In this study we identified the Forkhead factor FoxQ1 as increased in expression during TGF-beta1 induced changes i...
ORGANISM(S): Mus musculus 
2010-09-01 | E-GEOD-23833 | biostudies-arrayexpress
TranscriptomicsExpression data from renal primary epithelial cells
Autosomal dominant polycystic kidney disease (ADPKD) is characterized by the formation of multiple fluid-filled cysts that destroy the kidney architecture resulting in end-stage renal failure. Mutations in the ADPKD genes PKD1 and PKD2 account for nearly all the cases of ADPKD. Increased cell prolif...
ORGANISM(S): Rattus norvegicus 
2010-05-19 | E-GEOD-11500 | biostudies-arrayexpress
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