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ProteomicsOmega-3 fatty acid supplementation improves skeletal muscle mitochondrial function in a model of Barth syndrome
The composition of mitochondrial membrane lipids is crucial to cellular respiration, as seen in Barth syndrome (BTHS), a rare disease affecting skeletal muscle, heart, and neutrophils. In BTHS, mutations in the tafazzin (TAZ) gene reduce remodeling of the mitochondrial phospholipid, cardiolipin, res...
ORGANISM(S): Mus musculus (Mouse) 
2026-05-28 | PXD077710 | Pride
Barth syndrome Fish oil diet Tafazzin 
ProteomicsThe bile acid-CoA ligase, FATP5, is necessary for synthesis of N-acyl taurines in the liver
N-acyl taurines (NAT) are endogenous, bioactive conjugates of fatty acids and taurine with roles in glucose and lipid metabolism. In the liver, NATs share the taurine conjugation enzyme, bile acid-CoA:amino acid N-acyltransferase (BAAT), with bile acids, suggesting the potential of an overlapping he...
ORGANISM(S): Mus musculus (Mouse) 
2026-02-27 | PXD070306 | Pride
Nat Bile acids and salts/biosynthesis Slc27a5 Bile acids and salts/metabolism Lipids Fatty acid/transport Liver 
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