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ProteomicsDoxycycline treated cytotoxic T lymphocytes
Recent work in immunometabolism has emphasised the role of mitochondria in both the innate and adaptive immune system. Mitochondria are important in T cell development and differentiation, but less is known about their role in CD8+ effector T cells (CTLs). We found that CTLs that lack the mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD026948 | Pride
T cell Dia Mouse Ctl Protein translation Doxycycline Mitochondria 
ProteomicsActinomycin D treated cytotoxic T lymphocytes
Effector cytotoxic T lymphocytes (CTLs) are critical for ridding the body of infected or cancerous cells. Recognition of an antigenic ligand by the CTL’s T cell receptor (TCR) triggers a signalling cascade that ultimately results in the targeted release of cytolytic granules and/or secretion of cyto...
ORGANISM(S): Mus musculus (Mouse) 
2023-10-16 | PXD034920 | Pride
T cell Transcription Dia Mouse Actinomycin d 
ProteomicsProteome of WT and Usp30KO cytotoxic T lymphocytes
Recent work in immunometabolism has emphasised the role of mitochondria in both the innate and adaptive immune system. Mitochondria are important in T cell development and differentiation, but less is known about their role in CD8+ effector T cells (CTLs). We found that CTLs that lack the mitochondr...
ORGANISM(S): Mus musculus (Mouse) 
2022-06-09 | PXD021508 | Pride
Lc-msms Usp30 Dia Mouse T lymphocyte 
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