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ProteomicsNrf2 sequesters Keap1 preventing podosome disassembly
Nrf2 is a transcription factor playing an essential role in stress response. A knowledge of the significance of Nrf2 in cell function has not, as yet, reached out beyond transactivation of gene expression. This paper shows that GDF-15 and SDF-1-induced angiogenesis strongly depends on Nrf2 presence,...
ORGANISM(S): Homo sapiens (Human) 
2018-11-28 | PXD009161 | Pride
Cells Human 
ProteomicsKeap-1-mediated S-nitrosylation of NOX4 hampers oxidative damage in endothelium
ABSTRACT Rationale Premature senescence is conducive to aging and cardiovascular diseases. Nrf2 transcription factor, the master orchestrator of adoptive response to cellular stress, has been implicated in regulation of premature senescence in fibroblasts, neural and mesenchymal stem cells by trans...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD013640 | Pride
Endothelial cells S-nitrosylation Nrf2 Nox4 Oxidative stress 
ProteomicsKeap1 governs ageing-induced protein aggregation in endothelial cells
The breach of proteostasis, leading to the accumulation of protein aggregates, is a hallmark of ageing and age-associated disorders, up to now well-established in neurodegeneration. Few studies have addressed the issue of dysfunctional cell response to protein deposition also for the cardiovascular ...
ORGANISM(S): Homo sapiens (Human) 
2020-08-12 | PXD018969 | Pride
Aggregates Keap1 Human 
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