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Signalling pathways drive heterogeneity of ground state pluripotency
Pluripotent stem cells (PSCs) can self-renew indefinitely while maintaining the ability to generate all cell types of the body. This plasticity is proposed to require heterogeneity in gene expression, driving a metastable state which may allow flexible cell fate choices. Contradicting this, naive PS...
ORGANISM(S): Mus musculus 
2024-07-23 | GSE116565 | GEO
Genetic background is a major driver of the phenotypic variability observed across pluripotent stem cells (PSCs), and studies addressing it have relied on transcript abundance as the primary molecular readout of cell state. However, little is known about how proteins, the functional units in the cel...
ORGANISM(S): Mus musculus (Mouse) 
2023-05-10 | PXD033001 | Pride
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