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TranscriptomicsTranscription profiling of mouse expressing non-cleavable transmembrane mutant form of murine TNFalpha, or treated with soluble TNFalpha (20ng/ml) for 4 hours to investigate divergent and convergent effects on gene expression and function in acute versus chronic endothelial activation
Activation of the vascular endothelium with cytokines such as TNF is widely used to study the role of the vasculature in proinflammatory disease. To gain insight into mechanisms of prolonged vascular endothelial activation we compared changes in gene expression induced by continuous activation in st...
ORGANISM(S): Mus musculus 
2009-04-23 | E-GEOD-4518 | biostudies-arrayexpress
TranscriptomicsProfiling the transcriptional response upon deletion of PUN1
Yeast filamentous growth is a stress response to conditions of nitrogen deprivation, wherein yeast colonies form pseudohyphal filaments of elongated and connected cells. As proteins mediating adhesion and transport are required for this growth transition, the protein complement at the yeast cell pe...
ORGANISM(S): Saccharomyces cerevisiae 
2010-02-17 | E-GEOD-20351 | biostudies-arrayexpress
TranscriptomicsRoot transcriptome comparison between grapevines Cabernet Sauvignon, 140 Ruggeri and K51-40 (+/- salt stress)
Salt tolerance in grapevine is associated with the exclusion of chloride ions (ClM-bM-^@M-^S) from the shoot. The rate-limiting step for this process has been identified as the passage of ClM-bM-^@M-^S between the root symplast and the xylem apoplast through membrane integral proteins. To identify c...
ORGANISM(S): Vitis x champinii x Vitis riparia 
2014-09-30 | E-GEOD-57770 | biostudies-arrayexpress
TranscriptomicsIdentification of putative targets of Nkx2-5 in Xenopus laevis using gene expression analysis and cross-species.
This SuperSeries is composed of the following subset Series: GSE29791: Identification of putative targets of Nkx2-5 in Xenopus laevis using gene expression analysis and cross-species annotation GSE29795: Gene expression profile for X.laevis embryo head vs.tail Refer to individual Series
ORGANISM(S): Xenopus laevis 
2011-12-01 | E-GEOD-29816 | biostudies-arrayexpress
TranscriptomicsIdentification of putative targets of Nkx2-5 in Xenopus laevis using gene expression analysis and cross-species annotation
While the heart is the first organ to form during development, the earliest molecular mechanisms surrounding specification and differentiation are not clear. In vertebrates, the first marker of cardiac specification is the expression of the homeobox transcription factor Nkx2-5 and its paralogs. Whil...
ORGANISM(S): Xenopus laevis 
2011-12-01 | E-GEOD-29791 | biostudies-arrayexpress
TranscriptomicsGene expression profile for X.laevis embryo head vs.tail
This dataset was used to as a filter to annotate the results from another experiment (GSE29791). We used these results to find genes that were enriched in the head regions. In this way, we could eliminate more ubiquitously expressed genes. St. 18 embryos were bisected and RNA was collected from head...
ORGANISM(S): Xenopus laevis 
2011-12-01 | E-GEOD-29795 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of differential gene expression in muscle from Holstein Friesian bulls undergoing diet restriction and compensatory growth
The objective of this study was to examine changes in muscle gene expression of growing bulls during a period of dietary energy restriction followed by a period of subsequent realimentation and compensatory growth. Purebred Holstein Friesian bulls (n=20) were assigned to one of two feeding treatment...
ORGANISM(S): Bos taurus 
2015-09-04 | E-GEOD-64289 | biostudies-arrayexpress
ProteomicsMetabolic versatility of the nitrite-oxidizing bacterium Nitrospira marina and its proteomic response to oxygen-limited conditions
In this study, we investigated the metabolic potential of N. marina based on its complete genome sequence and performed physiological experiments to test genome-derived hypotheses. Our data confirm that N. marina benefits from additions of undefined organic carbon substrates, has adaptations to res...
ORGANISM(S): Nitrospira marina Nb-295 
2021-04-20 | PXD021606 | Pride
Lc-msms Nitrospira marina Thermo orbitrap 
ProteomicsAtmospheric hydrogen oxidation extends to the domain archaea
Diverse aerobic bacteria use atmospheric hydrogen (H2) and carbon monoxide (CO) as energy sources to support growth and survival. Though recently discovered, trace gas oxidation is now recognised as a globally significant process that serves as the main sink in the biogeochemical H2 cycle and sustai...
ORGANISM(S): Acidianus brierleyi 
2024-02-26 | PXD040286 | Pride
Hydrogen metabolism Archaea Microbiology Archaeal physiology Trace gas oxidation Acidianus Environmental microbiology 
MetabolomicsMetabolic differences between primary and brain metastatic breast tumors revealed by in vivo [U-¹³C]-glucose infusion in mice

Metastatic breast tumors must adapt to the metabolic constraints of their target tissues. To understand how tumor metabolism varies across sites, we compared glucose utilization in primary mammary fat pad (MFP) tumors and brain metastases derived from the breast cancer cell line MDA-MB-231. Tumor...

2025-12-30 | MTBLS13152 | MetaboLights
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