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MetabolomicsGDF15 hijacks B cells to fuel the lifeblood of tumor salvage pyrimidine synthesis
B cell-tumor crosstalk has emerged as a critical determinant of tumor progression; however, its role in metabolic reprogramming and therapeutic resistance remains poorly understood. Here, we uncover a metabolic feedback loop that drives resistance to dihydroorotate dehydrogenase (DHODH) inhibitors. ...
2026-09-27 | MTBLS15820 | MetaboLights
TranscriptomicsProfiling of growth and differentiation factor 15 regulated genes in hepatoma cells
To systematically profile the GDF15-regulated genes in hepatoma cells and to elucidate the possible role of GDF15 on biological processes, high-density oligonucleotide microarrays were hybridized with samples prepared from GDF15- or PBS-treated Huh7.5.1 cells. We found that a total of 894 genes were...
ORGANISM(S): Homo sapiens 
2010-11-18 | E-GEOD-25397 | biostudies-arrayexpress
UnknownPathophysiological role of growth differentiation factor 15 (GDF15) in obesity, cancer, and cachexia.
Not available
S-EPMC8957514 | biostudies-literature
ProteomicsThe Yin and Yang of GDF15: a secreted biomarker of eribulin response in breast cancer cells, yet required for survival of drug tolerant persister (DTP) cells
Drug tolerant persister (DTP) cells enter into a reversible slow-cycling state after cancer drug treatment. These cells are the living proof of response to a drug, and an interesting experimental subject for biomarker discovery. Here, we performed proteomic characterization of the breast cancer (BC)...
ORGANISM(S): Homo sapiens (Human) 
2023-01-09 | PXD034037 | Pride
Eribulin Drug tolerance Growth differentiation factor (gdf15) Secretome. Drug tolerant persister (dtp) Breast cancer (bc) 
UnknownRole of GDF15 (growth and differentiation factor 15) in pulmonary oxygen toxicity.
Not available
S-EPMC4553106 | biostudies-literature
GenomicsRole of growth differentiation factor 15 in mouse adipose tissue homeostasis
Role of growth differentiation factor 15 in mouse adipose tissue homeostasis
PRJNA1136038 | ENA
TranscriptomicsGDF15 overexpression dreived from tumor-associated macrophages and cancer cells in the microenvironment of human esophageal squamous cell carcinoma promotes tumor growth and poor prognosis
Tumor-associated macrophages (TAMs) are known to be involved in progression, angiogenesis and motility of various cancers. We have previously reported the association between increased number of infiltrating TAMs with tumor progression and poor prognosis in esophageal squamous cell carcinomas (ESCCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-59948 | biostudies-arrayexpress
UnknownCirculating Growth Differentiation Factor 15 (GDF15) in Paediatric Disease: A Systematic Review.
Not available
S-EPMC11870081 | biostudies-literature
UnknownMapping growth differentiation factor-15 (GDF15)-mediated signaling pathways in cancer: insights into its role across different cancer types.
Not available
S-EPMC11933546 | biostudies-literature
UnknownDepletion of growth differentiation factor 15 (GDF15) leads to mitochondrial dysfunction and premature senescence in human dermal fibroblasts.
Not available
S-EPMC9835581 | biostudies-literature
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