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ProteomicsProteome of Fam134A/B/C knock-out MEFs
Selective degradation of endoplasmic reticulum (ER) via autophagy receptors is important to maintain cell homeostasis. In this study we identify FAM134A/RETREG2 and FAM134C/RETREG3 as bona fide ER-phagy receptors containing a classical and functional LIR motif. In contrast to the other family member...
ORGANISM(S): Mus musculus (Mouse) 
2021-06-23 | PXD021690 | Pride
Fam134 Er-phagy Collagen Proteome 
ProteomicsCritical functions of FAM134 family members in endoplasmic reticulum remodeling, ER-phagy and collagen quality control
Degradation of the endoplasmic reticulum (ER) by selective autophagy (ER-phagy) is vital for cellular homeostasis. Here, we introduce FAM134A/RETREG2 and FAM134C/RETREG3 as new ER-phagy receptors. FAM134A and FAM134C exist in a relatively inactive state under basal conditions and require an activati...
ORGANISM(S): Homo sapiens (Human) 
2021-06-23 | PXD025626 | Pride
Collagen Fam134 Endoplasmic reticulum Er-phagy Retreg Autophagy U2os. 
UnknownElectron tomography - Myotubes:Fam134bKO and WT
Not available
EMPIAR-12473 | biostudies-other
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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